As early as 1909 plans for an Arts Building were proposed for the University of Saskatchewan campus. In the early years of the University David Brown and Hugh Vallance, the original campus architects had in fact designed a building for the Humanities. The building was to have been named Haultain Hall after Sir Frederick Haultain, Premier of the North West Territories from 1891-1905 and Chancellor of the University of Saskatchewan from 1917-1940.

Finally in 1957 funding for the construction of an Arts building materialized. In that year the Canada Council provided a grant to the University of Saskatchewan for the construction of the Arts Building. The grant was part of a greater program designed to fund the construction of facilities for the Humanities at Universities across Canada. In May of 1957 University President Walter Thompson obtained an agreement from the Provincial Government to provide for one-half of the funds for the Arts Building as well as full funding toward the construction of an Animal Husbandry and a Biology Building.

The Indian Head Methodist Church held its first services on July 29, 1883 in the CPR Railway Station. On May 24, 1925, the congregation voted to unite with the Presbyterians into the United Church.

The Saskatchewan Cancer and Medical Research Institute was officially opened on 10 May 1958 by Premier T.C. Douglas. Clad in locally quarried greystone with limestone panels, it was the last of the buildings that constituted the University’s Medical Complex’s initial phase. Designed by Izumi, Arnott and Sugiyama and completed at a cost of $783,000, the building’s purpose was to provide shared accommodation for both general medical research and cancer specific investigations. Funding came from the federal and provincial governments and the provincial and national branches of the Canadian Cancer Society. A planned third floor was added in 1966. The building was "deconstructed" in 2009, with much of the building's material recycled including the greystone cladding for use with the E Wing that opened in 2013.

Designated as a provincial heritage property in 1982 and as a National Historic Site in 2001, the University of Saskatchewan's first building has long served as the architectural, intellectual and emotional cornerstone of the campus. Designed by Brown and Vallance, the College Building was originally intended ultimately to house the College of Agriculture; but from the start, served numerous purposes. As early as April 1910, the floor plan included space for milk testing, butter making, cheese making, grain work; a gymnasium; several classrooms; offices for the Registrar, Dean of Agriculture, Director of Extension, and President; the original "faculty club"; laboratories; the library; and quarters for the janitor. After a sod-turning ceremony on 4 May 1910, the cornerstone was laid by Prime Minister Wilfrid Laurier on 29 July 1910. It was constructed between 1910-1912 by Smith Bros. and Wilson general contractors. Completed in 1912, the building was officially opened by Walter Scott, Premier of Saskatchewan, on 1 May 1913. The College Building serves as a memorial to much of the University's history: numerous plaques to individuals and organizations can be found in its interior, including memorial ribbons honouring members of the university community who served in the First World War. In 1997, the University created "Nobel Plaza" in front of the College Building, honouring two Nobel Laureates associated with the University: Gerhard Herzberg and Henry Taube. As the University grew, the College Building gradually became the administrative centre for the University. By the 1950s, most of the original teaching facilities were taken over by new or expanded offices including those of the registrar, controller, alumni and news services, and presidential staff. The building became known as the Administration Building at this point, and later the "old Administration Building" to distinguish it from the new wing. This expansion continued through the 1960s and 1970s, particularly with the appointment of a university secretary and vice-presidents. While Convocation Hall became too small for regular Convocation ceremonies by 1930, it maintained its original, broader function as a venue for concerts, meetings, lectures, and other events. Parts of the building were declared to be unsafe in 1979, which led to the construction of the new wing of the Administration Building, opened in 1987. Most of the original building was closed, but Convocation Hall remained in use until 1997. The building was reopened and officially rededicated as the College Building in September 2005 after a major rehabilitation project. The rehabilitation was reported to be "one of the largest heritage conservation projects in Canada - second only to the work being done on Parliament Hill." In addition to senior administrative offices and Convocation Hall, it became home to the Museum of Antiquities and new gallery space for the University Art Collection. Upon completion in 2012 the University Board of Governors renamed the Administration Building the Peter MacKinnon Building, in honour of Peter MacKinnon, retiring University President and a driving force behind the project.

In 1958 the federal government leased a three-acre site in what was then the north end of campus from the University for $1 a year. On that site was built the PFRA-Peterson Building, home of the northern Saskatchewan PFRA (Prairie Farm Rehabilitation Act) regional group. Staff worked on planning for the Gardiner Dam, soil conservation, and provided a variety of technical services to its prairie clientele. Sold to the University of Saskatchewan in 1998 for $1, the building's name refers to Bob Peterson, PFRA's first soil mechanics and materials engineer who was involved in the design and construction of many of the PFRA dams in Western Canada.

The construction of the Geology Building marked a return to the early style of campus architecture. The Department of Geology had been formed in 1927 and for the next six decades was based in the east wing of the Engineering Building. A growing faculty and student population had forced the department to cobble together makeshift accommodation in trailers and remote campus buildings. Designed by the architectural firm Black, McMillan and Larson of Regina, the building was given a neo-Collegiate Gothic exterior to blend harmoniously with the other buildings in the central campus. The two-and-a-half-storey building was erected just south or the bowl side of the W.P. Thompson Biology Building providing 8,543 square metres for office, laboratory, library, classroom, and storage space for rock and fossil samples. The exterior was clad with greystone and dressed with tyndal limestone. The dominant feature of the interior was a two story atrium that featured the mosaics for the former exterior walls of the Thompson Building, a life-size skeleton of a Tyrannosaurus Rex and geological and biological displays.

The $18.5 million Geology Building was completed in 1986 and fused the space between Physics and Biology and linked, through a walkway, with Chemistry, creating an integrated science complex on campus.

Original plans for the Agriculture Building had it joining Kirk Hall, the John Mitchell Building and Crop Science, but the architects, Folstad-Friggstad, instructed to provide “a highly visible complex for the College,” proposed a stand-alone building intended to state the importance of the College of Agriculture to the University. It is the first major building on campus clad with glass rather than brick or stone.

The original structure cost $91,000,000 and was constructed between 1988-1991. It consisted of five floors, with 164 research labs, 38 teaching labs, 182 offices, 9 classrooms, 4 computer training facilities, 6 conference rooms, and 167 controlled environment plant growth facilities. In addition it has an impressive inner courtyard, the Atrium, and is home to the Kenderdine Gallery, named in honour of the University’s first art instructor.

Numerous private and corporate donors contributed to the building fund.

The structure had been designed to enable future expansion, and by 2000 a sixth floor was added at a construction cost of $10,000,000. The new addition was intended to house Animal and Poultry Science, Food Science, and Bioinsecticide Research.

The first major recreational facility on campus, “The Rink” was also the last major construction project completed before the combination of depression and war stopped all capital expansion. Designed by G.J.K. Verbeke, the rink was completed in 1929, at a cost of $47,000. Later renovations were made in 1980 and 1986.

Built on a site previously used for an open outdoor rink, construction of “The Rink” was due to student initiative. A campaign to have a closed rink facility began in 1920; by 1928, the Students Representative Council appointed a committee to look into the feasibility of the student body assuming responsibility for construction. The Board of Governors loaned SRC the funds; which the student council hoped to pay back by instituting a $3 student fee.

Although opened for use in December 1929 the rink, “already the most popular place on campus,” had its official opening on 23 January 1930, with an inter-varsity hockey game against the University of Manitoba (Saskatchewan won, 5-1). 650 attended the opening; and between 18-20,000 people used the rink during its first year of operation. The original design included “waiting rooms” on the west and east side, “primarily” for use by men and women respectively. The rink was used for general skating, “scrub,” faculty, senior men’s and girls’ varsity team hockey practices, the “fancy skating club,” children’s skating, and band practice. Speed skates were allowed, but the rink was “not responsible for injury resulting therefrom.” During general skating, “playing tag,” “cutting in,” “cracking the whip,” and “reckless disregard and abandon in speed skating” were not tolerated.

The building was renamed in honour of W.J. Rutherford, the University’s first Dean of Agriculture, whose “deep interest in everything pertaining to the well-being of his fellow citizens enabled him to render a service, not only to Agriculture and to Education, but to national affairs that has rarely been surpassed in this Province.” Rutherford’s sudden and unexpected death on 1 June 1930 was considered “a national loss.”

Originally named the Chemistry Building, the Thorvaldson Building was designed by Architect David R. Brown of Montreal. Although preliminary drawings for the building were complete in 1913, the structure was not built until 1924 due to the disruption of the First World War, followed by economic constraints.