Regina St. John's Pastoral Charge was formed around 1954, part of Regina Presbytery and containing the new St. John's United Church, built at McTavish Street and Fourth Avenue, Regina. The decision to have a new building had resulted from a presbytery Church Extension Committee survey (ca.1951) that determined the district of the city required facilities not available at the existing Sixth Street United Church. The first service in the new St. John's United Church was held November 14, 1954. The pastoral charge closed June 30, 1999.

Saskatoon McClure Pastoral Charge was formed as as a new United Church charge around 1967, under Saskatoon Presbytery.

Wiseton Pastoral Charge was formed as a new United Church charge in 1925, part of Saskatoon Presbytery (then Elrose Presbytery in 1926) and consisting of preaching points at Wiseton, Forgan, Lion's Head and Buffalo Hill. In the late-1940s, the charge amalgamated with Dinsmore to form Wiseton-Dinsmore Pastoral Charge, with preaching points at Dinsmore, Forgan, and Wiseton. By 1951, the charge (listed as Wiseton Pastoral Charge) consisted of Wiseton, Dinsmore, Forgan and Coteau-View appointments. As of 1962, only Wiseton, Dinsmore and Forgan remained (the last of which was no longer listed by 1976).

On March 1, 2006, the charge joined with the Milden preaching point (previously part of Wheatlands Pastoral Charge) to create the new Prairie Spirit Pastoral Charge.

Wynyard Pastoral Charge was formed as a new United Church charge in 1925, containing preaching points at Wynyard, Little Quill and Harvard. On March 31, 1997, the charge amalgamated with Foote-Copeland Pastoral Charge, forming the new Living Shamrock Pastoral Charge.

The charge was formed as Saltcoats-Bredenbury Pastoral Charge, around 1959, from an amalgamation of Saltcoats and Bredenbury Pastoral Charges. Initial preaching points included Castleton, Churchbridge, Bredenbury, Langenburg, Rokeby, Saltcoats, and Tonkin. Several of the points later closed and/or moved, including Langenburg, which became part of Cutarm Pastoral Charge.

In later years, preaching points included: Knox United Church, in Bredenbury; St. Andrew's United Church, in Churchbridge; and Saltcoats United Church. The preaching point at Churchbridge was closed June 29, 1999, the rest of the charge joined with Langenberg to create Saltcoats-Bredenbury-Churchbridge-Langenburg Pastoral Charge (later re-named Four Town Pastoral Charge), on July 1, 1999.

Aneroid Pastoral Charge was formed as a new United Church charge in 1925, containing preaching points at Aneroid, Kincaid (Glencaid), and Ponteix. By 1932, Ponteix had formed its own Charge and Aneroid Pastoral Charge points were listed as Aneroid, Cananea, Pinto River and Quimper. As of 1951, points consisted of Aneroid, Pinto River and Hazenmore. The charge amalgamated with Cadillac-Neville-Vanguard Pastoral Charge, to create New Venture Pastoral Charge, April 8, 1995.

Arcola-Kisbey Pastoral Charge was formed July 1, 2008, from an amalgamation of Arcola Pastoral Charge and Kisbey-Lampman Pastoral Charge.

Hawarden Pastoral Charge was formed as a new United Church charge in 1925, part of Moose Jaw Presbytery, with preaching points at Hawarden, Strongfield and Glenford. By 1951, the charge consisted of just Hawarden and Strongfield and the minister came from Loreburn. Sometime before 1958, the charge and closed and, by 1962, Hawarden and Loreburn had joined to create Loreburn-Hawarden Pastoral Charge, with preaching points at Bonnie View, Elbow, Hawarden, Loreburn, Strongfield, and South Sask. River Development.

The United Church of Canada was formed in 1925, from a union of the Congregational Union of Canada, the Methodist Church and 70% of the Presbyterian Church in Canada, along with a number of churches organized under the General Council of Local Union Churches (mostly in Western Canada). Saskatchewan Conference was one of eleven regional Conferences established by the United Church of Canada General Council, at their inaugural meeting, in June 1925. Initially, the Conference contained 16 presbyteries but this number varied, in the years that followed.

In January 2019, as part of a larger restructuring of the United Church of Canada, Saskatchewan Conference and its seven existing presbyteries were combined into a single entity, initially identified as Region 4 and later renamed Living Skies Regional Council.

Arcola-Estevan Presbytery was created from the amalgamation of Arcola Presbytery and Estevan Presbytery, in 1951. In 1973, Arcola-Estevan Presbytery was combined with part of Assiniboia Presbytery, becoming the new Souris Valley Presbytery.

Cypress Hills Presbytery was created, in 1959, from the merger of Swift Current Presbytery and the part of Assiniboia Presbytery west of Highway 19.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Cypress Hills Presbytery became part of the new Chinook Presbytery.

Qu’Appelle Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Qu’Appelle Presbytery, which had been part of the Presbyterian Synod of Saskatchewan.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Qu’Appelle Presbytery became part of the new Twin Valleys Presbytery.

Saskatoon Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Saskatoon Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Saskatchewan District, in the Saskatchewan Conference of the Methodist Church.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Saskatoon Presbytery became part of the new River Bend Presbytery.