In 1908, the Basis of Union was formulated that would eventually lead to the creation of the United Church of Canada in 1925. Coinciding with this spirit of unity, the first Union church (Presbyterian and Methodist) was set up in Melville, Saskatchewan in 1908, followed a short time later by the church in Frobisher. In 1912, a committee of Union Churches approached the national church courts of the Presbyterian, Methodist, and Congregational denominations in order to seek affiliation with the parent churches. This committee formed the nucleus of what would become the General Council of Union Churches of Western Canada. An Advisory Council, with representatives of the Union Churches and the parent churches, was established in 1914 as a means of creating the sought after link between the Union Churches and the parent churches.

Moose Jaw College was initially established (by the Presbyterian Synod of Saskatchewan) as a residential college for young men. The cost of the buildings was raised by public subscription and the site officially opened in September 1913, on a 45-acre site near River Park, in Moose Jaw, Saskatchewan. From 1925 until the early 1930s (when it closed), the principal was Rev. Angus A. Graham.

The congregation at Knox Presbyterian Church appears to date back to around 1882, building a church in 1885, at the corner of Scarth Street and 11th Avenue, and a later replacement in 1905. Knox joined the United Church of Canada in 1925. In 1951, Knox United Church amalgamated with Metropolitan United Church, to become Knox-Metropolitan United Church (and Pastoral Charge), located on the site of the former Metropolitan United Church, at the corner of Victoria Avenue and Lorne Street.

The Dominion Commission (officially "The Commission appointed pursuant to The United Church Act, chapter 100 of the Statutes of Canada, 1924") was formed to enable the distribution of property between the United Church of Canada, which about 70% of Presbyterian Churches in Canada joined, and the remaining "non-concurring" Presbyterian Church.