Melville Pastoral Charge was formed as a new United Church charge in 1925, containing First United Church, in Melville. This congregation is generally considered the first Local Union formed in Canada, dating back to 1908 and coinciding with the Basis of Union, which eventually lead to the creation of the United Church of Canada. Original members included Methodists, Baptists, Congregationalists, and Presbyterians.

Regina Carmichael Pastoral Charge was formed as a new United Church charge in 1925, containing the Carmichael United Church preaching point. The church had been originally formed (in 1925) by congregations at the former Wesley Methodist Church and Carmichael Presbyterian Church, named after a former Presbyterian Superintendent of Missions, Dr. James Carmichael. The charge closed June 30, 1995.

Star City Pastoral Charge was formed as a new United Church charge in 1925, part of Prince Albert Presbytery and containing Star City, Campbellville, and Valparaiso appointments. By 1951, only Star City and Valparaiso remained in the charge. Brooksby was later added (before 1962) and Valparaiso removed (ca.1965).

Tugaske Pastoral Charge was formed as a new United Church charge in 1925, part of Moose Jaw Presbytery and containing just the Tugaske preaching point.

Between 1946 and 1951, Tugaske and Eybrow Pastoral Charges amalgamated to form Tugaske-Eyebrow Pastoral Charge, with appointments at Bridgeford, Brownlee, Eskbank, Eyebrow, and Tugaske. Lake Valley was added around 1965 and Keeler around 1982. Brownlee amalgamated with Keeler in 1986 and eventually closed, on June 30, 1996.

The charge amalgamated with Central Butte Pastoral Charge, on July 1, 2007, forming the new Spirit Hills Pastoral Charge.

Weyburn Pastoral Charge was formed as a new self-sustaining United Church charge in 1925, part of Weyburn Presbytery.

Foxdale Pastoral Charge was formed around 1926, as an aid-receiving United Church charge, part of Prince Albert Presbytery. By 1932, the charge included Foxdale, Canwood, Silver Cliff and Sturgeon River points, and was listed as Canwood-Foxdale Pastoral Charge. As of 1936, the name had shifted to Canwood Pastoral Charge and it consisted of just Canwood, Polwarth and Silver Cliff. Marchant Grove was added and Silver Cliff removed by 1940. Sometime between 1946 and 1951, the points moved into Shellbrook Pastoral Charge.

Around 1972, Canwood moved from Shellbrook Pastoral Charge (which became Shellbrook-Leask) to Big River Pastoral Charge, which was re-named Big River - Canwood Pastoral Charge. Canwood's Trinity United Church closed March 30 2010, leaving just Big River's First United Church and the charge would return to the name Big River Pastoral Charge.

Maple Creek Pastoral Charge was formed as a new United Church charge in 1925, containing preaching points at Maple Creek and Motherwell.

Spiritwood Pastoral Charge was created between 1926 and 1932, part of Prince Albert Presbytery and consisting of preaching points at Spiritwood, Bapaume and Mildred. By 1936, the Mildred point had moved to Shell Lake Pastoral Charge. Around 1940, the charge appears to have been dissolved, with Spiritwood joining Rothermere Pastoral Charge, in Battleford Presbytery.

Around 1965, the Spiritwood Pastoral Charge re-emerged, part of Prince Albert Presbytery and consisting of Spiritwood, Shell Lake, Twin Bay, Ranger, and Chitek Lake. By 1969, Shell Lake and Spiritwood were the only remaining points. As of 1984, the charge consisted of Chitek Lake (Summer), Glaslyn (Bissell Memorial), Shell Lake (Grace) and Spiritwood (Bissell Memorial). On June 30, 2002, Bissel Memorial Church, in Spiritwood, was re-named Trinity Bissell Memorial United Church. The charge was officially re-named Partners in Faith (Shared Ministry), on June 17, 2014.

Asquith Pastoral Charge was formed as a new United Church charge in 1925, part of Saskatoon Presbytery and containing preaching points at Asquith, Poplar Crescent and McTavish. By 1932, the charge had become Asquith-Kinley Pastoral Charge, containing Asquith and Kinley appointments. The name shifted back to Asquith Pastoral Charge by 1936. As of 1962, preaching points were listed as Asquith, Arelee, and Environ (the latter had left or closed by 1969). In 1981, the Arelee point had moved from Asquith to Perdue Pastoral Charge. On July 1, 1999, the charge amalgamated with Perdue to become Asquith-Perdue Pastoral Charge.

Saskatoon Bethel Pastoral Charge was formed between 1925 and 1940, part of Saskatoon Presbytery. The original Bethel United Church was built at 905 - 5th Street in 1927, as Clarence Avenue Mission, then was renamed Bethel United Church, in 1929. As of 1940, it was listed as an aid-receiving charge, with a student minister and additional preaching points at Blackley and Floral. By 1951, it was listed as Saskatoon Bethel-Floral Pastoral Charge but it returned to the name Bethel Pastoral Charge by 1958. The charge closed June 30, 2011.

Neville-Vanguard Pastoral Charge was created around 1942, from the amalgamation of Neville Pastoral Charge and Vanguard Pastoral Charge. Initial preaching points included Daybreak, Neville, Pambrum, Titanic and Vanguard. As of 1951, points consisted of Pambrum and Vanguard. Around 1969, after Cadillac Pastoral Charge was dissolved, the preaching point was added to Neville-Vanguard, creating the Neville-Vanguard-Cadillac Pastoral Charge.

Qu'Appelle Pastoral Charge was formed as a new United Church charge in 1925, part of Qu'Appelle Presbytery and consisting of appointments at Qu'Appelle and Edgeley. The congregation at Qu'Appelle can be traced to Presbyterian and Methodist congregations from at least the 1880s, which joined in 1925, creating Knox United Church, in the former Presbyterian building (built ca.1907, replacing a previous 1886 building). The Methodist Qu'Appelle Circuit (formed ca.1882) had served congregations in Qu'Appelle and Edgeley, both of which also built churches, in 1883.

By 1962, Qu'Appelle Pastoral Charge points at Qu'Appelle and Edgeley had been joined by McLean and Avonhurst (formerly McLean Pastoral Charge). By 1969, Avonhurst was no longer listed in the charge. On April 1, 1989, Edgeley and McLean separated and formed their own pastoral charges. In 2018, the remaining Qu'Appelle Knox Pastoral Charge was disbanded. (The separate Edgeley Pastoral Charge continued on.)

Regina St. John's Pastoral Charge was formed around 1954, part of Regina Presbytery and containing the new St. John's United Church, built at McTavish Street and Fourth Avenue, Regina. The decision to have a new building had resulted from a presbytery Church Extension Committee survey (ca.1951) that determined the district of the city required facilities not available at the existing Sixth Street United Church. The first service in the new St. John's United Church was held November 14, 1954. The pastoral charge closed June 30, 1999.