Originally known as the Veterinary Infectious Disease Organization, VIDO was established at the University of Saskatchewan in 1975. VIDO is a research organization of the University of Saskatchewan that operates with financial support from the Government of Canada, the government of Saskatchewan, livestock industry councils and agencies, foundations and human and animal health companies. VIDO worked to find cures for common infectious diseases in cattle, swine and poultry. VIDO scientists carved out an international reputation for their pioneering work in the 1980's on vaccines aimed at combating shipping fever and a disease which produces pneumonia and arthritis in cattle. In addition to the 2,500,000 sq ft facility on campus, VIDO-InterVac also operates a 160-acre research station. The laboratory took on its current name, International Vaccine Centre (VIDO-InterVac), in March 2003. In October 2003 a large expansion was completed. In March 2004, VIDO received funding for the construction one of the world's largest and most advanced biosafety level 3 facilities, the International Vaccine Centre (InterVac), for research into emerging and reemerging human and animal diseases. In 2020, VIDO-InterVac began developing a vaccine for SARS-CoV-2 during the COVID-19 pandemic.

It was established with a grant provided by the Devonian Group of Charitable Foundations of Calgary, and with supplementary funding from the provincial governments of Alberta and Saskatchewan, the University, and subsequently a great many livestock and poultry organizations. VIDO represented a new and unique model for funding practical goal-oriented research, and established an international reputation by developing several new vaccines to prevent neonatal diarrhea, or scours, in newborn calves (Vicogen, Ecostar, Ecostar 2RC); Haemophilus somnus infection of cattle (Somnu-Star and Somu-Star Ph); shipping fever pneumonia in cattle (Pneumo-Star); pneumonia in pigs (Pleuro-Star); and adenovirus infection in turkeys (Hevlan-TC). It also developed new management and disease prevention programs for cattle and swine. In 2003, VIDO changed its name and opened an expansion to its building that now provides 80,000 square feet of ultramodern laboratory space for a staff of 145 researchers. It uses the most modern research tools of genomics and bioinformatics to develop new vaccines and vaccine delivery technology.

Stephen Acres

The Virus Laboratory Building was constructed from 1947-1948, and was designed by the architectural firm of Webster and Gilbert. It was located on what is now a grassy area in front of the Western College of Veterinary Medicine. The construction of the building was financed with proceeds from the sale of the equine encephalomyelitis vaccine. The disease equine encephalomyelitis, more commonly known as "sleeping sickness," first appeared in Saskatchewan in 1935. It recurred in 1937 and 1938, when it killed an estimated 13,000 to 15,000 horses. The vaccine was developed by Dr. Fulton in the late 1930s while he was still head of the Veterinary Sciences Department, and was first sold by the University in 1939. While commercial production companies in the United States were selling a similar vaccine for $1.80 per dosage, the University undersold them at 75 cents – which accounted for all the funding available for construction. Dr. Fulton also demonstrated that a human disease previously diagnosed as non-paralytic poliomyelitis was in fact caused by the same virus, at which time he produced a vaccine for humans. Demolition of the J.S. Fulton Virus Laboratory was completed in 1989.

In the summer of 1914, the Canadian militia leased a part of the Sarcee (now Tsuu T'ina Nation) Indian Reserve as a prospective training site for military personnel. Sarcee Camp, as the site came to be known, was the only area in Alberta set aside to train soldiers for battle during World War I. More than 45,000 men from 30 units across the province trained at the camp over the course of the war. It was one of the largest military training areas in Canada at the time. Sarcee Camp was abandoned in 1998.