Prince Albert Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Prince Albert Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union , in 1925, there had also been a Prince Albert District, in the Saskatchewan Conference of the Methodist Church.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Prince Albert Presbytery became part of the new Tamarack Presbytery.

Regina Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Regina Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Regina District, in the Saskatchewan Conference of the Methodist Church.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Regina Presbytery became part of the new Wascana Presbytery.

Rosetown Presbytery was created in 1949, through the amalgamation of Elrose and Kindersley Presbyteries. Additional charges transferred over the years, including Springwater (moved from Battleford Presbytery, July 1, 1985).

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Rosetown Presbytery became part of the new Prairie Pine Presbytery.

Swift Current Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Swift Current Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Swift Current District, in the Saskatchewan Conference of the Methodist Church.

In 1959, the presbytery was amalgamated with part of Assiniboia Presbytery (west of Highway 19) and became Cypress Hills Presbytery.

Wilkie Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Wilkie Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Wilkie District, in the Saskatchewan Conference of the Methodist Church.

On July 1, 1961, the presbytery officially amalgamated with Battleford Presbytery, except for two pastoral charges (Biggar and Springwater), which became part of Rosetown Presbytery.

River Bend Presbytery was one of the 7 presbyteries of Saskatchewan Conference created in 2000. It was initially comprised of pastoral charges from the former Saskatoon Presbytery. In January 2019, as part of a larger restructuring of the United Church of Canada, River Bend Presbytery was combined with Saskatchewan Conference and the other remaining presbyteries to become Region 4.