Kindersley Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Kindersley Presbytery, part of the Presbyterian Synod of Saskatchewan, as well as Rosetown Methodist District and some Independent Union Charges. Prior to 1925, there had also been a Kindersley District, in the Saskatchewan Conference of the Methodist Church.

Pastoral charges in 1925 included: Eatonia, Elrose, Luseland, Netherhill, Rosetown, Plenty, Wartime, Madison, Jellico, Superb, White, Bear, Kerrobert, Major, Coleville, Valley Centre, Herschel, Dodsland, Alsask, Hoosier, Loverna, Fiske, Flaxcombe, Kindersley, Eston, Ferndale, and Plato. By the summer of 1926, the presbytery also contained 12 stations served by student ministers: Beadle, Belvoir, Buckley, Dewar Lake, Idaleen, Kingsland, Mantario, Oliver, Kyle, Stanrear, Richlea, and Tuberose.

In 1926, Kindersley Presbytery was divided, with part of it creating the new Elrose Presbytery. The two reunited in 1949, amalgamating to become Rosetown Presbytery.

Prince Albert Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Prince Albert Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union , in 1925, there had also been a Prince Albert District, in the Saskatchewan Conference of the Methodist Church.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Prince Albert Presbytery became part of the new Tamarack Presbytery.

Qu’Appelle Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Qu’Appelle Presbytery, which had been part of the Presbyterian Synod of Saskatchewan.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Qu’Appelle Presbytery became part of the new Twin Valleys Presbytery.

Regina Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Regina Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Regina District, in the Saskatchewan Conference of the Methodist Church.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Regina Presbytery became part of the new Wascana Presbytery.

Rosetown Presbytery was created in 1949, through the amalgamation of Elrose and Kindersley Presbyteries. Additional charges transferred over the years, including Springwater (moved from Battleford Presbytery, July 1, 1985).

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Rosetown Presbytery became part of the new Prairie Pine Presbytery.

Saskatoon Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Saskatoon Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Saskatchewan District, in the Saskatchewan Conference of the Methodist Church.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Saskatoon Presbytery became part of the new River Bend Presbytery.

Shaunavon Presbytery was created from the split of Assiniboia Presbytery, in 1926. In 1951, the two were reunited under the original name Assiniboia Presbytery.

Souris Valley Presbytery was created from the amalgamation of Arcola-Estevan Presbytery with part of Assiniboia Presbytery (the other part joined Moose Jaw Presbytery), ca.1973.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Souris Valley Presbytery became part of the new Twin Valleys Presbytery.

Swift Current Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Swift Current Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Swift Current District, in the Saskatchewan Conference of the Methodist Church.

In 1959, the presbytery was amalgamated with part of Assiniboia Presbytery (west of Highway 19) and became Cypress Hills Presbytery.

Prairie Pine Presbytery was one of the 7 presbyteries of Saskatchewan Conference created in 2000. It was initially comprised of pastoral charges from the former Battleford Presbytery and Rosetown Presbytery. In January 2019, as part of a larger restructuring of the United Church of Canada, Prairie Pine Presbytery was combined with Saskatchewan Conference and the other remaining presbyteries to become Region 4.

Tamarack Presbytery was one of the 7 presbyteries of Saskatchewan Conference created in 2000. It was initially comprised of pastoral charges from the former Prince Albert Presbytery. In January 2019, as part of a larger restructuring of the United Church of Canada, Tamarack Presbytery was combined with Saskatchewan Conference and the other remaining presbyteries to become Region 4.

Wascana Presbytery was one of the 7 presbyteries of Saskatchewan Conference created in 2000. It was initially comprised of pastoral charges from the former Regina Presbytery. In January 2019, as part of a larger restructuring of the United Church of Canada, Wascana Presbytery was combined with Saskatchewan Conference and the other remaining presbyteries to become Region 4.