In 1908, the Basis of Union was formulated that would eventually lead to the creation of the United Church of Canada in 1925. Coinciding with this spirit of unity, the first Union church (Presbyterian and Methodist) was set up in Melville, Saskatchewan in 1908, followed a short time later by the church in Frobisher. In 1912, a committee of Union Churches approached the national church courts of the Presbyterian, Methodist, and Congregational denominations in order to seek affiliation with the parent churches. This committee formed the nucleus of what would become the General Council of Union Churches of Western Canada. An Advisory Council, with representatives of the Union Churches and the parent churches, was established in 1914 as a means of creating the sought after link between the Union Churches and the parent churches.

The United Church of Canada was created in 1925, from the union of Presbyterian, Methodist, Congregationalist and Local Union churches. The women’s organizations from the uniting denominations at the time included: the Canada Congregational Woman's Board of Missions (mostly in eastern Canada, since 1886); the Women’s Missionary Society of the Methodist Church (founded 1876); the Woman's Missionary Society of the Presbyterian Church in Canada, Eastern Division (founded 1825) and Western Division (founded 1876); along with their various corresponding regional and local units. Soon after union, these became national, regional and local units of the United Church of Canada Woman’s Missionary Society (W.M.S.).

The new Society had its first annual meeting in 1926. Like the earlier societies, it brought the message of missions before the entire community of the Church, while offering financial support and personnel to its own wide mission programme.

In 1962, United Church W.M.S. and W.A. organizations across the country amalgamated to form the United Church Women (U.C.W.). Presbyterial and local groups developed along similar lines to national bodies, becoming local and presbyterial U.C.W. units in January 1962.

North Battleford Pastoral Charge was formed as a new United Church charge in 1925, from what had previously been the North Battleford Methodist Circuit and Presbyterian North Battleford Pastoral Charge. Presbyterians in the area who were "non-concurring" with Union continued as Presbyterians, under the Presbyterian Church in Canada.

Hurricane Hills Pastoral Charge was formed as a new United Church charge in 1925, as part of Qu'Appelle Presbytery and primarily consisting of the Hurricane Hills preaching place. In 1984, it joined the new Plains Presbytery, which became part of the All Native Circle Conference when it was formed, in 1989.

Moose Jaw Trinity Pastoral Charge was formed as a new United Church charge in 1925, from what had previously been the Moose Jaw Wesley Methodist Circuit. Around 1960, Grandview United Church joined the charge, which was renamed Trinity-Grandview Pastoral Charge. On June 30, 2001, the joint-charge was officially dissolved and the congregations formed separate charges, including the re-formed Trinity Pastoral Charge.

Prince Albert Wesley Pastoral Charge was formed as a new United Church charge in 1925, part of Prince Albert Presbytery and consisting of Wesley United Church (Prince Albert). It was closed July 1, 2018.

The Board of Women became operational in 1961, as the Woman's Missionary Society was disbanded, with the goal of deepening women's knowledge of and participation in the mission of the Church. More specifically the Board was to supervise and promote the organization of women at the congregational, Presbytery and Conference levels through the development of the United Church Women. This included leadership development, mission, worship and development of resources such as Clip Sheet, an irregular issue-oriented publication, and reports from the Reading and Viewing Committee. In addition, the Outreach Committee attempted to inform women in the Church about social and economic issues affecting Canadian society including drug abuse, poverty, single parent families and native Canadians. In some fashion the Board revived aspects of the home mission activity of the Woman's Association, with committees on Christian Citizenship and Social Action, Community Friendship and Visitation, and Leadership Development.

The Board included a Chairman, Secretary and Associate Secretaries, as well as representatives of several Boards of the Church and of the Conference United Church Women. In 1964 the Board became part of the Division of Congregational Life and Work while maintaining its independence of action. The Board was was absorbed into the new Division of Mission in 1972. The Secretaries were Anne I. Ward, 1961-1969; and K. Harriet Christie, 1970-1972.

The Board of Men was established in 1954 as a successor to the National Committee of United Church Men, itself a successor to the Committee on Lay Activities. In 1964 the Board became part of the Division of Congregational Life and Work while maintaining its independence of action. It was absorbed into the Division of Mission in Canada in 1972.

Its purpose was to lead laymen into a deeper spiritual life and involvement with the Church's work and programmes. A main function was to promote the formation of men's groups, not only by working with existing United Church Men's clubs, fellowships, and brotherhoods in the pastoral charges, but also by working with newly created United Church Men's Councils at the Presbytery and Conference levels. The goal was to integrate all men's work programmes, in particular by bringing the Western Canada-based AOTS men's club movement fully into the Board structure. This was accomplished in stages: first by making the AOTS National Council a department of the Board (since 1952), then by changing this department into a more integrated National Association of United Church AOTS Men's Clubs in 1959, and finally by making this the Men's Club Committee (more directly responsible for all types of U.C. men's clubs) of the Board in 1964. The first National Conference of United Church Men was held in Muskoka, Ont., in 1953, and became an annual event; annual national conferences were also held in Western Canada (Banff) starting in 1955, and in Atlantic Canada from 1964. The Board had additional responsibilities for leadership development (Elders and Stewards Schools), "Christianity and Daily Work" concerns, and for producing pamphlets, booklets, national newsletters, and printed materials for Laymen's Sunday. It worked co-operatively with many Church departments and agencies, particularly in the areas of recruiting Church workers and lay employees, Boy's and Youth Work, the Lay School of Theology, Lay Foundations for assisting theological students, and Operation Crossroads Africa.

Secretaries of the Board were: Ralph C. Young, 1954-1961; Donald Cameron (Acting Secretary), 1961-1964; Ralph F. Wilson, 1965-1969; and Donald G. Smith (Associate Secretary), 1970-1972.

The Division grew out of the Board of Colleges and an expanded vision of vocation in the church, and was established in 1971 to serve the personnel, educational and vocational needs of the Church. Of particular interest to the Division was the role of pastoral work, chaplaincy in institutions, continuing education for clergy and lay supplies, theological education, recruitment, summer supplies, and special training programmes.

Under the major reorganization of General Council units in 2001, the mandate of the Division of Ministry Personnel and Education was moved to two units: Faith Formation and Education (FFE) and Ministry and Employment Policy and Services (MEPS).

The Young People's Union (Y.P.U.) of the United Church and its Conference-level units were organized around 1935, following the recommendation of the Interprovincial Young People's Council (1934). Saskatchewan Conference's Y.P.U. appears to have been formed sometime after the first National Y.P.U. Council, in mid-1935.

In 1965, the United Church Y.P.U. and its constituent Conference- and Presbytery-level groups appear to have been reorganized to form units of Kairos.