Estevan Presbytery was the new name given to Alameda Presbytery, by the first Saskatchewan Conference (October 1925). As Alameda Presbytery, it was one of the original 16 that were established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries for both Alameda Presbytery and Weyburn Presbytery were to follow the recommendation of a joint meeting of Alameda and Weyburn Presbyteries, from the Presbyterian Synod of Saskatchewan, and the Weyburn District of the Methodist Saskatchewan Conference.

In 1951, Arcola and Estevan Presbyteries amalgamated, becoming the Arcola-Estevan Presbytery.

Arcola-Estevan Presbytery was created from the amalgamation of Arcola Presbytery and Estevan Presbytery, in 1951. In 1973, Arcola-Estevan Presbytery was combined with part of Assiniboia Presbytery, becoming the new Souris Valley Presbytery.

Arcola Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Arcola Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to 1925, there had also been an Arcola District, in the Methodist Saskatchewan Conference.

In 1951, Arcola and Estevan Presbyteries amalgamated and became Arcola-Estevan Presbytery.

Yorkton Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Yorkton Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Yorkton District, in the Saskatchewan Conference of the Methodist Church.

In 1953, pastoral charges from part of Abernethy Presbytery (east of Highway 35) were added and the combined presbytery was re-named Abernethy-Yorkton. In 1956, after a merger of Abernethy-Yorkton and Kamsack Presbyteries, the new combined body returned to the name Yorkton Presbytery. The name was changed to Parkland Presbytery in 1992.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Parkland Presbytery became part of the new Good Spirit Presbytery.

Abernethy-Yorkton Presbytery was created in 1953, through the merging of Yorkton Presbytery and part of Abernethy Presbytery (east of Highway 35). In 1956, Abernethy-Yorkton amalgamated with Kamsack Presbytery and the resulting body returned to the earlier name, Yorkton Presbytery.

Abernethy Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Abernethy Presbytery, which had been part of the Presbyterian Synod of Saskatchewan.

In 1953, the pastoral charges in Abernethy Presbytery were divided and moved to other presbyteries: Nokomis Pastoral Charge was added to Saskatoon Presbytery; other charges located west of Highway 35 were reassigned to Regina Presbytery; and the charges east of Highway 35 were moved to Yorkton Presbytery, which was re-named Abernethy-Yorkton Presbytery.

The United Church of Canada was formed in 1925, from a union of the Congregational Union of Canada, the Methodist Church and 70% of the Presbyterian Church in Canada, along with a number of churches organized under the General Council of Local Union Churches (mostly in Western Canada). Saskatchewan Conference was one of eleven regional Conferences established by the United Church of Canada General Council, at their inaugural meeting, in June 1925. Initially, the Conference contained 16 presbyteries but this number varied, in the years that followed.

In January 2019, as part of a larger restructuring of the United Church of Canada, Saskatchewan Conference and its seven existing presbyteries were combined into a single entity, initially identified as Region 4 and later renamed Living Skies Regional Council.

The congregation at Knox Presbyterian Church appears to date back to around 1882, building a church in 1885, at the corner of Scarth Street and 11th Avenue, and a later replacement in 1905. Knox joined the United Church of Canada in 1925. In 1951, Knox United Church amalgamated with Metropolitan United Church, to become Knox-Metropolitan United Church (and Pastoral Charge), located on the site of the former Metropolitan United Church, at the corner of Victoria Avenue and Lorne Street.

Built around 1912, Metropolitan Methodist Church became Metropolitan United Church in 1925 (part of the United Church of Canada). It was later re-named Knox-Metropolitan United Church, with the amalgamation of downtown Regina's Knox United Church and Metropolitan United Church.