Kindersley Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Kindersley Presbytery, part of the Presbyterian Synod of Saskatchewan, as well as Rosetown Methodist District and some Independent Union Charges. Prior to 1925, there had also been a Kindersley District, in the Saskatchewan Conference of the Methodist Church.

Pastoral charges in 1925 included: Eatonia, Elrose, Luseland, Netherhill, Rosetown, Plenty, Wartime, Madison, Jellico, Superb, White, Bear, Kerrobert, Major, Coleville, Valley Centre, Herschel, Dodsland, Alsask, Hoosier, Loverna, Fiske, Flaxcombe, Kindersley, Eston, Ferndale, and Plato. By the summer of 1926, the presbytery also contained 12 stations served by student ministers: Beadle, Belvoir, Buckley, Dewar Lake, Idaleen, Kingsland, Mantario, Oliver, Kyle, Stanrear, Richlea, and Tuberose.

In 1926, Kindersley Presbytery was divided, with part of it creating the new Elrose Presbytery. The two reunited in 1949, amalgamating to become Rosetown Presbytery.

Kamsack Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Kamsack Presbytery, which had been part of the Presbyterian Synod of Saskatchewan.

In 1956, Kamsack Presbytery amalgamated with Abernethy-Yorkton Presbytery, becoming Yorkton Presbytery.

In 1908, the Basis of Union was formulated that would eventually lead to the creation of the United Church of Canada in 1925. Coinciding with this spirit of unity, the first Union church (Presbyterian and Methodist) was set up in Melville, Saskatchewan in 1908, followed a short time later by the church in Frobisher. In 1912, a committee of Union Churches approached the national church courts of the Presbyterian, Methodist, and Congregational denominations in order to seek affiliation with the parent churches. This committee formed the nucleus of what would become the General Council of Union Churches of Western Canada. An Advisory Council, with representatives of the Union Churches and the parent churches, was established in 1914 as a means of creating the sought after link between the Union Churches and the parent churches.

Estevan Presbytery was the new name given to Alameda Presbytery, by the first Saskatchewan Conference (October 1925). As Alameda Presbytery, it was one of the original 16 that were established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries for both Alameda Presbytery and Weyburn Presbytery were to follow the recommendation of a joint meeting of Alameda and Weyburn Presbyteries, from the Presbyterian Synod of Saskatchewan, and the Weyburn District of the Methodist Saskatchewan Conference.

In 1951, Arcola and Estevan Presbyteries amalgamated, becoming the Arcola-Estevan Presbytery.

Arcola-Estevan Presbytery was created from the amalgamation of Arcola Presbytery and Estevan Presbytery, in 1951. In 1973, Arcola-Estevan Presbytery was combined with part of Assiniboia Presbytery, becoming the new Souris Valley Presbytery.