Wilkie Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Wilkie Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Wilkie District, in the Saskatchewan Conference of the Methodist Church.

On July 1, 1961, the presbytery officially amalgamated with Battleford Presbytery, except for two pastoral charges (Biggar and Springwater), which became part of Rosetown Presbytery.

Chinook Presbytery was one of the 7 presbyteries of Saskatchewan Conference created in 2000. It was initially comprised of pastoral charges formerly part of Cypress Hills Presbytery and Moose Jaw Presbytery. In January 2019, as part of a larger restructuring of the United Church of Canada, Chinook Presbytery was combined with Saskatchewan Conference and the other remaining presbyteries to become Region 4.

Good Spirit Presbytery was one of the 7 presbyteries of Saskatchewan Conference created in 2000. It was initially comprised of pastoral charges formerly part of Parkland Presbytery (previously Yorkton Presbytery). In January 2019, as part of a larger restructuring of the United Church of Canada, Good Spirit Presbytery was combined with Saskatchewan Conference and the other remaining presbyteries to become Region 4.

Prairie Pine Presbytery was one of the 7 presbyteries of Saskatchewan Conference created in 2000. It was initially comprised of pastoral charges from the former Battleford Presbytery and Rosetown Presbytery. In January 2019, as part of a larger restructuring of the United Church of Canada, Prairie Pine Presbytery was combined with Saskatchewan Conference and the other remaining presbyteries to become Region 4.

River Bend Presbytery was one of the 7 presbyteries of Saskatchewan Conference created in 2000. It was initially comprised of pastoral charges from the former Saskatoon Presbytery. In January 2019, as part of a larger restructuring of the United Church of Canada, River Bend Presbytery was combined with Saskatchewan Conference and the other remaining presbyteries to become Region 4.

Tamarack Presbytery was one of the 7 presbyteries of Saskatchewan Conference created in 2000. It was initially comprised of pastoral charges from the former Prince Albert Presbytery. In January 2019, as part of a larger restructuring of the United Church of Canada, Tamarack Presbytery was combined with Saskatchewan Conference and the other remaining presbyteries to become Region 4.

Wascana Presbytery was one of the 7 presbyteries of Saskatchewan Conference created in 2000. It was initially comprised of pastoral charges from the former Regina Presbytery. In January 2019, as part of a larger restructuring of the United Church of Canada, Wascana Presbytery was combined with Saskatchewan Conference and the other remaining presbyteries to become Region 4.

Plains Presbytery was created in 1984, consisting of Cote, File Hills, Hurricane Hills, Moose Woods and White Bear Pastoral Charges. In 1989, the presbytery moved from Saskatchewan Conference to join the newly created All Native Circle Conference.

Initially called Region 4, Living Skies Regional Council was formed in January 2019 from a combination of Saskatchewan Conference and its seven existing presbyteries. As of 2020, the region includes about 170 Pastoral Charges and 230 congregational communities of faith, as well as 5 outreach ministries and 5 camps.