Initially called Region 4, Living Skies Regional Council was formed in January 2019 from a combination of Saskatchewan Conference and its seven existing presbyteries. As of 2020, the region includes about 170 Pastoral Charges and 230 congregational communities of faith, as well as 5 outreach ministries and 5 camps.

The United Church of Canada was created in 1925, from the union of Presbyterian, Methodist, Congregationalist and Local Union churches. The women’s organizations from the uniting denominations at the time included: the Canada Congregational Woman's Board of Missions (mostly in eastern Canada, since 1886); the Women’s Missionary Society of the Methodist Church (founded 1876); the Woman's Missionary Society of the Presbyterian Church in Canada, Eastern Division (founded 1825) and Western Division (founded 1876); along with their various corresponding regional and local units. Soon after union, these became national, regional and local units of the United Church of Canada Woman’s Missionary Society (W.M.S.).

The new Society had its first annual meeting in 1926. Like the earlier societies, it brought the message of missions before the entire community of the Church, while offering financial support and personnel to its own wide mission programme.

In 1962, United Church W.M.S. and W.A. organizations across the country amalgamated to form the United Church Women (U.C.W.). Presbyterial and local groups developed along similar lines to national bodies, becoming local and presbyterial U.C.W. units in January 1962.

The Provincial Church Union Committee was formed on July 26, 1923, by representatives of the Saskatchewan Methodist Conference and the Presbyterian Synod of Saskatchewan to take preliminary steps to effect Church Union in Saskatchewan. Representatives of the congregational Churches were also invited to be on the committee.

D.S. Dix was a prominent Presbyterian and then United Church clergyman, whose work included serving as minister to Saskatoon's Westminster Church, as lecturer and professor at the Presbyterian Theological College – which became St. Andrew's College – in Saskatoon, as Principal of St.Andrew's College, and as President of Saskatchewan Conference.

Born in 1875, in Woodbridge (York County), Ontario, Dix trained as a teacher and taught for 6 years before enrolling in the Presbyterian Knox College (University of Toronto). He graduated with a degree in theology, in 1907, and pursued further studies in divinity at Glasgow University (Scotland), the University of Chicago, and Union Seminary (New York). He served as minister to St. James Church (Dartmouth, Nova Scotia), 1908-1910, to Chalmers Church (Guelph, Ontario), 1910-1913, and Westminster Church (Saskatoon), 1913-1919. Dix was also a lecturer and then professor at the Presbyterian Theological College, which became St. Andrew's College (Saskatoon), under its first Principal, Rev. E.H. Oliver. In 1935, Dix was appointed Principal of the College, after the death of E.H. Oliver.

In June 1946, Dix officially retired but remained associated with St. Andrew's College. He served on the United Church Board of Overseas Missions and as President of Saskatchewan Conference (1934-1935). He was Conference Archivist (1947-1953), and chairman of the Conference Historical Committee until his death, in 1956.

Emerick Csendes was a missionary and later United Church minister in Saskatchewan and Manitoba. He was born in Transylvania, southeast Hungary, in October 1886. From 1914-1919, he served in the army and was promoted to the rank of Lieutenant. In 1924, Csendes left to become a missionary in Western Canada. He worked with Hungarian congregations in Manitoba and Saskatchewan – at Bekevar and Otthon – and studied at St. Andrew’s College (Saskatoon), from 1925 to 1928. He served in Winnipeg from 1929 until 1934, when he transferred to the Rothermere Mission field (Battleford Presbytery). In 1940, he returned to Otthon-Halmok Patoral Charge (Yorkton Presbytery), where he remained until 1951, when he transferred to Toronto’s Church of All Nations. He retired around 1956.

R.W. Hardy was a Methodist and later United Church minister, who served congregations in Saskatchewan and British Columbia. He was born in 1890 and spent his childhood in Ontario, before attending the University of Toronto. He was ordained and married in June 1921, in Whitby, Ontario. He moved west and was assigned by the Methodist Church to the hospital in Hafford, Saskatchewan. From 1925 to 1930, Hardy served as a United Church minister in Speers and then Maymont, before transferring to Cranbrook, B.C.

The Dominion Commission (officially "The Commission appointed pursuant to The United Church Act, chapter 100 of the Statutes of Canada, 1924") was formed to enable the distribution of property between the United Church of Canada, which about 70% of Presbyterian Churches in Canada joined, and the remaining "non-concurring" Presbyterian Church.

Norman Scott was a United Church minister, who served various congregations in Saskatchewan and worked as Christian Education Field Secretary, in Regina. Ordained in 1954, his ministry included pastoral charges in Uranium City (1954–1956), Shellbrook (1957–1960) and Tisdale (1961–1965). From 1966 to 1973, he served as Field Secretary (Christian Education) in Regina. He was Staff Officer in Edmonton, Alberta (1973–1979), then minister to South Arm, in Richmond, B.C., before retiring, in 1989.

G.G. Heffelfinger was a Presbyterian and later United Church minister, whose Saskatchewan pastorates included Buchanan, Grenfell, Vanscoy, Melfort, Sixth Avenue United Church (Regina), and Watrous.

Born in Nebraska, Heffelfinger and his family moved to Drinkwater, Saskatchewan, in 1907. He attended the University of Saskatchewan, receiving his Bachelor of Arts degree in 1916. During the First World War, he served as a stretcher-bearer with the Canadian Medical Corps (12th Field Ambulance) overseas, and was awarded the Military Medal. After the war, Heffelfinger pursued theological training, at New College (Edinburgh) and St. Andrew's College (Saskatoon), and was ordained by the Presbyterian Church, in 1921. He married Jean Watkins, in 1922.

Heffelfinger served as minister in Buchanan, Saskatchewan, 1921–1924, and Fort William, Ontario, 1924–1929. He received his Bachelor of Divinity degree from United College (Winnipeg). Returning to Saskatchewan, he served in Grenfell, 1929–1933, Vanscoy, 1933–1934, Melfort, 1934–1936, and Oxbow, 1937–1942. After receiving a Bachelor of Education degree, he became Saskatchewan director for the Canadian Legion Educational Services.

After the Second World War, Heffelfinger served as minister at Sixth Avenue (later called St. John's) United Church, in Regina, 1946–1956, then at Atwood and Springfield (London Conference), in Ontario, until he retired, in 1962. Returning to Saskatchewan, he came out of retirement to serve as minister to Watrous, where he remained from 1962–1964.

Homer Lane was a United Church minister, who served in several Saskatchewan congregations, including Carnduff, Weyburn, Carmichael (Regina), St. Andrew's (Moose Jaw), and Knox-Metropolitan (Regina).

Born in 1904, to Methodist parents, Lane studied Arts and Theology at United College, in Winnipeg, before pursuing post-graduate studies at Emmanuel College, Toronto, and receiving his Bachelor of Divinity Degree. He was ordained in 1929 and served as Boy's Work Secretary for Manitoba and Saskatchewan. He married Grace Grover in 1932. In addition to his other work, Lane also served as Assistant Secretary of the United Church Board of Evangelism and Social Services for the Prairie Region, and later became Associate Secretary of the Board. In 1950, he was elected President of Saskatchewan Conference. After his term, Lane was honoured with a Doctor of Divinity Degree from United College (Winnipeg).