In 1908, the Basis of Union was formulated that would eventually lead to the creation of the United Church of Canada in 1925. Coinciding with this spirit of unity, the first Union church (Presbyterian and Methodist) was set up in Melville, Saskatchewan in 1908, followed a short time later by the church in Frobisher. In 1912, a committee of Union Churches approached the national church courts of the Presbyterian, Methodist, and Congregational denominations in order to seek affiliation with the parent churches. This committee formed the nucleus of what would become the General Council of Union Churches of Western Canada. An Advisory Council, with representatives of the Union Churches and the parent churches, was established in 1914 as a means of creating the sought after link between the Union Churches and the parent churches.

Kamsack Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Kamsack Presbytery, which had been part of the Presbyterian Synod of Saskatchewan.

In 1956, Kamsack Presbytery amalgamated with Abernethy-Yorkton Presbytery, becoming Yorkton Presbytery.

Kindersley Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Kindersley Presbytery, part of the Presbyterian Synod of Saskatchewan, as well as Rosetown Methodist District and some Independent Union Charges. Prior to 1925, there had also been a Kindersley District, in the Saskatchewan Conference of the Methodist Church.

Pastoral charges in 1925 included: Eatonia, Elrose, Luseland, Netherhill, Rosetown, Plenty, Wartime, Madison, Jellico, Superb, White, Bear, Kerrobert, Major, Coleville, Valley Centre, Herschel, Dodsland, Alsask, Hoosier, Loverna, Fiske, Flaxcombe, Kindersley, Eston, Ferndale, and Plato. By the summer of 1926, the presbytery also contained 12 stations served by student ministers: Beadle, Belvoir, Buckley, Dewar Lake, Idaleen, Kingsland, Mantario, Oliver, Kyle, Stanrear, Richlea, and Tuberose.

In 1926, Kindersley Presbytery was divided, with part of it creating the new Elrose Presbytery. The two reunited in 1949, amalgamating to become Rosetown Presbytery.

Prairie Pine Presbytery was one of the 7 presbyteries of Saskatchewan Conference created in 2000. It was initially comprised of pastoral charges from the former Battleford Presbytery and Rosetown Presbytery. In January 2019, as part of a larger restructuring of the United Church of Canada, Prairie Pine Presbytery was combined with Saskatchewan Conference and the other remaining presbyteries to become Region 4.

Prince Albert Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Prince Albert Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union , in 1925, there had also been a Prince Albert District, in the Saskatchewan Conference of the Methodist Church.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Prince Albert Presbytery became part of the new Tamarack Presbytery.