"The building is the first one, and for many years will occupy the place of honor, and even in later years, when the principal buildings have been built, its position is such that it deserves thorough study to develop the architectural possibilities." - David Brown to Walter Murray, 5 November 1909.

Designated as a provincial heritage property in 1982 and as a National Historic Site in 2001, the University's first building has long served as the architectural, intellectual and emotional cornerstone of the campus.

Designed by Brown and Vallance, the College Building was originally intended ultimately to house the College of Agriculture; but from the start, served numerous purposes. As early as April 1910, the floor plan included space for milk testing, butter making, cheese making, grain work; a gymnasium; several classrooms; offices for the Registrar, Dean of Agriculture, Director of Extension, and President; the original "faculty club"; laboratories; the library; and quarters for the janitor. After a sod-turning ceremony on 4 May 1910, the cornerstone was laid by Prime Minister Wilfrid Laurier on 29 July 1910. It was constructed between 1910-12 by Smith Bros. and Wilson general contractors. Completed in 1912, the building was officially opened by Walter Scott, Premier of Saskatchewan on 1 May 1913.

The College Building serves as a memorial to much of the University's history: numerous plaques to individuals and organizations can be found in its interior, including memorial ribbons honouring members of the university community who served in the First World War. In 1997, the University created "Nobel Plaza" in front of the College Building, honouring two Nobel Laureates associated with the University: Gerhard Herzberg and Henry Taube.

As the University grew, the College Building gradually became the administrative centre for the University. By the 1950s, most of the original teaching facilities were taken over by new or expanded offices including those of the registrar, controller, alumni and news services, and presidential staff. The building became known as the Administration Building at this point, and later the "old Administration Building" to distinguish it from the new wing.

This expansion continued through the 1960s and 1970s, particularly with the appointment of a university secretary and vice-presidents. While Convocation Hall became too small for regular Convocation ceremonies by 1930, it maintained its original, broader function as a venue for concerts, meetings, lectures, and other events.

Parts of the building were declared to be unsafe in 1979, which led to the construction of the new wing of the Administration Building, opened in 1987. Most of the original building was closed, but Convocation Hall remained in use until 1997.

The building was reopened and officially rededicated as the College Building in September 2005 after a major rehabilitation project. The rehabilitation was reported to be "one of the largest heritage conservation projects in Canada - second only to the work being done on Parliament Hill." In addition to senior administrative offices and Convocation Hall, the College Building became home to the Museum of Antiquities and new gallery space for the University Art Collection.

A Royal Commission was established on 24 August, 1951 to conduct and inquiry and to report on the South Saskatchewan River Project (Central Saskatchewan Development). The inquiry was to determine whether or not the economic and soical returns to the Canadian people would commensurate with the cost of the investment in the project. Dr. T.H. Hogg, G.A. Gaherty and Dr. John A. Widtsow were appointed commissioners

The first ski jump on the east bank of the South Saskatchewan River was built in 1929-1930 by the Saskatoon Ski Club with permission of the university. It was located at "Devil's Dip" and inaugurated on 18 Jan.1930. However, during the same season a jumper broke his leg and the ski jump had to be closed since the university withdrew its permission. Already in the following winter a new, larger ski jumping hill with an approximately 18-meter high tower was erected a few hundred meters north at "Varsity Site". The first record there was 97 feet (29.5 m) by Dave Wood. In 1933 a clubhouse was added and in 1936 the hill, which was also called "Ski Jump Coulee", was reconstructed and enlarged with a 25 meter high tower. The hill was then used for a few decades and competitions there even attracted up to 2,500 spectators. Furthermore, alpine slopes, a ski lift and a toboggan run were added at the site. Though interest in ski jumping had already been decreasing, the ski jump was reconstructed in 1963, reorienting the outrun from the river onto the bank and thus making the hill smaller. However, in 1974 ski jumping operations stopped and in 1978 it was torn down. In 1971 the Jeux Canada Winter Games were held at Saskatoon and for that purpose a new winter sports facility was opened at Mount Blackstrap, which made the other facilities at Varsity Site unnecessary as well. Off the trail are the remnants of the jump’s footings and tow lift.

The Shuttleworth Mathematical Society was designed to give students interested in mathematics an opportunity to meet in an informal setting, and was open to all students who had completed one math class and were registered in a second. The Society was originally formed in November 1916 as the University Mathematical Society. It was renamed in honour of Roy Eugene Shuttleworth, a brilliant honours student who had been the first president of the organization. Shuttleworth was born in 1896 in Leavenworth, Washington. He was a student at the University of Saskatchewan. He served as a private with the Princess Patricia's Canadian Light Infantry (Eastern Ontario Regiment). Shuttleworth died in combat during World War I on 26 August 1918 at Vimy Ridge, France. His name is inscribed on the Vimy Memorial. The society has been inactive for many years.

SED Systems grew out of Space Engineering Division of the Department of Physics at the University of Saskatchewan. Formed in 1965, SED initially designed and built rocket instrumentation for upper atmospheric testing, primarily for the National Research Council (NRC). It soon diversified and began designing aerospace and satellite systems technology related to the communications industry. Although SED had become a self-funding unit through contracts it was awarded, industry complaints of unfair competition prompted the establishment of SED as a limited liability company, owned by the University, in 1972. In 1985 SED made its first public share offering. Within a year, Fleet Aerospace Corporation (of Ontario) acquired controlling interest in SED.

In 1973, five Saskatoon women applied for and received an Opportunities For Youth grant. With little background in either research or women's history, they produced and published Herstory: The Canadian Women's Calendar, a calendar documenting the history and achievements of Canadian women. Since then, 50 women have at some time been members of the Saskatoon Women's Calendar Collective; the calendar's 20th edition was published in 1995. When the Collective started, the field of women's history was relatively new: Herstory quickly became, and has remained, a Canadian best-seller, despite a two year hiatus (1983-1984) when one publisher's failure demanded a lengthy search for a new publisher. Each calendar contains profiles of individual women or women's groups, essays on issues, or highlights the work of an author or artist.

Following passage of the Saskatchewan Pharmacy Act in 1911, the newly incorporated Saskatchewan Pharmaceutical Association requested the University of Saskatchewan undertake the training and examination of pharmacists. A School within the College of Arts and Science was established in 1913 and the following year, 22 students enrolled in a one-year certificate program following a three-year apprenticeship. In 1921 the School became a College offering a four-year course leading to a Bachelor of Science in Pharmacy. Three years later the certificate program was extended to two years. In 1946 the four-year BSP was a requirement for license in Saskatchewan. In 1987 a Division of Nutrition and Dietetics was established in the College of Pharmacy. Prior to this, Nutrition and Dietetics had been offered in the College of Home Economics. In 1994 the College was renamed the College of Pharmacy and Nutrition.

Established around 1977, the SIAP offered opportunities for Aboriginal peoples to learn about and gain skills in the agricultural sector. The 4-H program in particular offered these learning experiences to Aboriginal youth on reserves, making Saskatchewan the only Canadian province to have a separate 4-H program for Aboriginal youth. Donor Les Ferguson acted for a long period as the full-time 4-H coordinator, supported by eight Agriculture Extension staff. Common youth projects included woodwork, foods, clothing, traditional arts and crafts, and firearm safety. The 4-H Garden Project, the 4-H Poultry Project, and the 4-H swine project were particularly popular. Approximately 100 4-H leaders would work with the program each year. Costs would be shared equally between the Indian 4-H Program and the families involved. The SIAP was also a major organizer of the Saskatchewan Indian Youth Conference.

The Saskatchewan AIDS Network (SAN) was a coalition of community-based organizations dedicated to responding to HIV/AIDS at the provincial level through the development and maintenance of community partnerships. At the time of its formation in 1994, the founders believed that an organization was needed to facilitate co-operation and communication on a province-wide basis to deal with the HIV/AIDS crisis.

SAN was designed as a province-wide coalition in order to ensure that the voices of rural communities would be included and that the independent efforts of member organizations would contribute to collective goals. SAN had numerous objectives including: to support other service organizations and communities in their efforts to advocate for social change; to make HIV/AIDS a higher health priority for the general public in Saskatchewan; to develop more effective relationships with all levels of government and with other health and social justice coalitions; to provide opportunities for members to network, share information, build skills, and develop partnerships with one another; and to act as a resource centre for its members by providing access to up-to-date information, hard-to-find documents, and other HIV/AIDS-related resources.

The Board of Directors of SAN consisted of one representative from each member group of SAN. The SAN Steering Committee was responsible for the day to day operations of the coalition, for tasks on a provincial level (such as lobbying Ministers or building coalitions with other provincial groups), and for developing resource materials that would be helpful for member organizations. SAN membership was open to any Saskatchewan non-governmental organization that was dedicated to addressing HIV/AIDS in its organizational mandate. By the early 2000s, SAN was having difficulty meeting its mandate so it was dissolved in February 2003.

In the summer of 1914, the Canadian militia leased a part of the Sarcee (now Tsuu T'ina Nation) Indian Reserve as a prospective training site for military personnel. Sarcee Camp, as the site came to be known, was the only area in Alberta set aside to train soldiers for battle during World War I. More than 45,000 men from 30 units across the province trained at the camp over the course of the war. It was one of the largest military training areas in Canada at the time. Sarcee Camp was abandoned in 1998.

The Rutherford Memorial Trophy was first awarded around 1949 by the Saskatchewan Agricultural Graduates Association for competition during its annual Farm Week Bonspiel. The trophy honoured W.J. Rutherford, first dean of Agriculture. The names of all the members of the class of 1912 are engraved on a plate on the back of the trophy.

Rugby Chapel is situated on a parcel of land on the University of Saskatchewan campus adjoining College Drive. It features a wood frame, single story chapel constructed in 1911 on the site of the "College of Shacks". Heritage value of Rugby Chapel resides in its association with the history of Anglican education in Saskatchewan, and of the University of Saskatchewan. Constructed after the move of the Anglican Emmanuel College from Prince Albert to Saskatoon in 1908, Rugby Chapel is the first Anglican permanent place of worship built on the campus of the nascent University of Saskatchewan. Built with funds raised by students in Rugby, England, the chapel has served the needs of the Anglican community on campus for 54 years, gradually becoming a repository for religious artifacts associated with the Anglican tradition in Canada. Heritage value also lies in the chapel’s architecture and its historical integrity. Built in the Gothic Revival architectural style, it resembles the design of many English stone-built churches featuring a Norman tower with parapet, tracery and stained glass windows and exposed rafters. It is one of the few remaining Anglican places of worship in Saskatoon that is constructed of wood and one of the few wooden buildings remaining on the grounds of the University of Saskatchewan. Its interior and exterior have remained virtually unchanged since its construction (2022).

Designed by Webster and Gilbert, architects, and built between 1948 and 1955 by Smith Bros. and Wilson, contractors, at a cost of $7,000,000.00, the 6-storey, 7-wing University Hospital was officially opened by Bentley, T.J., Saskatchewan Minister of Health on May 1955.The name was officially changed to Royal University Hospital 23 May 1990.

From the Greek for ‘five and ten,’ Pente Kai Deka was created on 8 April 1911 with the first 15 women students on campus – five “big sisters” and ten “little sisters.” Every woman entering the University automatically became a member. Eventually the group became its own directorate within the Student Representative Council, and the PKD president, the vice-president of the SRC. Activities of the group included a Big Sister-Little Sister Dance, June in January, Jeanboree, a Spring Tea and a Frosh Week fashion show. As the sexual revolution loomed large in the late 1960s women on campus grew increasingly ambivalent toward the group, which had been seen by many female students as irrelevant and antiquated since midway through the decade. It was this attitude, as well as the sheer increase in the number of women and students in general at the University by the late 1960s that led to the group’s demise after the 1968-1969 academic year.

The North Atlantic Coast Fisheries Arbitration settled an economic dispute between Canada, the United States, and Great Britain over fishing rights. The dispute centered on the interpretation of several treaties granting American citizens special fishing rights in Canadian and Newfoundland waters. The dispute began in 1905 when Newfoundland introduced new regulations which restricted the fishing rights of American citizens and were enacted and enforced without notice to the Americans. The three countries were unable to settle the issue on their own so they agreed to take the case to the Permanent Court of Arbitration at The Hague. On September 7, 1910, the tribunal ruled that while Canada and Newfoundland had sovereignty over the waters in question, the reasonableness of any new regulations must be allowed to be challenged by the United States. All three countries were pleased with the ruling of the tribunal. Using the ruling, the three countries were able to agree to a new treaty, which was signed in 1912. The new treaty stipulated that at the end of the fishing season, Canada was required to notify the Americans of any new fishing regulations for the following season. The United States was given a set number of days to object to these new regulations. If they filed an objection, a commission would decide if the new regulations were reasonable. If the Americans did not object, then the new regulations were presumed to be reasonable and in effect.