Regina St. Andrew's Pastoral Charge was formed as a new United Church charge in 1925, from what had previously been a Presbyterian field. On June 30, 2014, the church was closed and the congregation amalgamated with Knox-Metropolitan.

Regina Knox Pastoral Charge was formed as a new United Church charge in 1925, containing the preaching point Knox United Church, formerly Knox Presbyterian Church. The previous Presbyterian congregation dated back to around 1882. It built a church in 1885, at the corner of Scarth Street and 11th Avenue, and a later replacement in 1905.

In 1951, Knox United Church amalgamated with Metropolitan United Church, to become Knox-Metropolitan United Church (and Pastoral Charge), located on the site of the former Metropolitan United Church, at the corner of Victoria Avenue and Lorne Street.

Regina Heritage Pastoral Charge was established January 1, 1984, from a preaching point previously part of Regina St. James Pastoral Charge.

Regina Eastside Pastoral Charge was created as Prince of Peace Pastoral Charge (from the main preaching point), a new church development, on September 6, 1987. On January 1, 1998, the charge was renamed Eastside Pastoral Charge.

Regina Carmichael Pastoral Charge was formed as a new United Church charge in 1925, containing the Carmichael United Church preaching point. The church had been originally formed (in 1925) by congregations at the former Wesley Methodist Church and Carmichael Presbyterian Church, named after a former Presbyterian Superintendent of Missions, Dr. James Carmichael. The charge closed June 30, 1995.