Though the first recorded withdrawal from the University Library occurred in October 1909, nearly five decades passed before the Library had its own building. The early collection was housed either on the second floor of the College Building, later known as the Administration Building, or was scattered among a number of small departmental libraries. Plans for a new library building in the late 1920s were ended by the start of the Great Depression; but a dramatically reduced acquisitions budget was offset by a grant from the Carnegie Corporation in 1933. In 1943 the University hired its first professional Librarian.

A combination of provincial grants and University fundraising financed the construction of the Murray Memorial Library. Named after the University’s first President, the H. K. Black design marked a change in campus architecture away from the more angular and elaborate Collegiate Gothic style to that of the less expensive cube. Building materials included granite at the entrance and Tyndall stone (the material greystone replaced in 1911) as a wall cladding and window trim. In addition to the library, the building housed the College of Law, an office of the Provincial Archives and a 105 seat lecture theatre equipped with the latest in audio visual teaching aids.

Over the next two decades the University Library System mirrored the expansion of the University in general. Branches were opened in Education, Health Sciences, Law, Engineering, Geography/Physics, Thorvaldson, and Veterinary Medicine. The most dramatic transformation took place between 1970 and 1976 when a six floor south wing was added along with an extensive renovation of the 1956 structure. Designed by BLM, Regina, the south wing was unlike any other building on campus. Clad in Tyndall stone panels made to look like concrete (through a "bush hammered" finish), the grey almost windowless building is industrial and utilitarian in appearance. The University's master plan required buildings in the core of campus to be clad in stone. However, the "bush hammered" finish was used since the Library addition was built during a period that saw the flowering of "Brutalist" Architecture, so called because of the wide use of exposed concrete. The new (south) wing, originally called the Main Library, was officially opened on 17 May 1974, and also became the home of the Department of Art and Art History, the College of Graduate Studies and the University Archives.

The President’s Residence is among the original buildings constructed on campus. The residence was designed by Brown and Vallance, and was built under the direction of A.R. Greig, Superintendent of Buildings and Grounds. The building was originally planned as a wooden structure. However, a proposal to construct the building out of a local river rock, later known as greystone, was raised prior to the commencement of construction - if the government would foot the bill. Eventually the latter material was chosen, though the government perhaps came to regret its decision. Construction on the President's Residence began in 1910 and finished in early 1913. By the time it was completed the original cost for the building had ballooned from $32,000 to $44,615. Walter Murray, the first president of the University, was deeply embarrassed by the cost of what was to be his personal residence, even though it was also a public building. However, the people of Saskatoon were proud of the building and the status it gave their University, and no public outcry over the cost ever materialized. Renovations to the President's Residence were completed in 1989 by PCL-Maxam at a cost of $96,752. The renovations were designed by architects Malkin/Edwards.

The Dean of Agriculture’s Residence, now the University Faculty Club, was among first buildings on campus. Designed by Brown & Vallance of Montreal, the original plan called for a wood-clad structure but this was abandoned when the Board of Governors decided to use local greystone in May, 1911. Unlike several of the larger buildings, the Dean’s Residence was built by university employees with the assistance of day labourers. Construction took less than a year and costs ran to nearly $25,000.

Sometimes known as “grey gables,” the building’s first resident was W.J. Rutherford. The location of the house, on the campus close to the University Farm, reflected the unique relationship of the Agricultural College with the University. In addition to a family residence, the adjourning grounds were used on occasion as the site for outdoor receptions and social gatherings. The last Dean to live in the house was V.E. Graham who moved out in 1961 so the building could be converted into a Faulty Club. The building underwent two more renovations in 1966 and 1975. The latter was the most extensive, cost $607,961, and established the footprint of the building as it exists today.

At 3:00 pm on 19 September 1972, a fire that had been smoldering in the roof insulation for hours became apparent inside the club. The building was evacuated and an alarm called into the City of Saskatoon Fire Department. Six units were eventually dispatched to battle the “stubborn” fire before a crowd of several hundred onlookers. No one was injured, the building was saved from catastrophic damage and it was soon functioning again as a friendly oasis for the members of faculty.