The fonds reflects the activities of the South Saskatchewan Hospital Centre, its Board of Governors, and the institutions under the Board's direction. Fonds consists of correspondence; minutes of the SSHC Board of Governors, committees and professional associations; studies and reports, including bed needs studies and long range strategic planning; contracts and agreements for laundry service and office space, and between the University of Saskatchewan and Regina Teaching Hospitals; policies and procedures; hospital accreditation records; reference materials including articles and brochures; statistics; financial records; records of construction and renovations; human resources records; organisational charts; photographs); conference files; subject files; annual reports; the SSHC Act; manuals; presentations; and legal records

Fonds also documents the relationship between the SSHC and the following external agencies, associations, and committees: Statistics Canada; Government of Canada Department of National Health and Welfare; Saskatchewan Department of Public Health; Saskatchewan Department of Government Services; Saskatchewan Department of Industry and Commerce; Saskatchewan Department of Occupational Health; Saskatchewan Cancer Foundation; Allan Blair Memorial Clinic; Wascana Centre Authority; College of Medicine, University of Saskatchewan; [Royal] University Hospital, Saskatoon; Canadian College of Health Service Executives; Regina Hospital Executives Planning Committee; Canadian Hospital Association; Saskatchewan Healthcare Associations; Saskatchewan Union of Nurses; and Regina Hospitals Liaison Committee on Medical Education Programs.

Fonds contains records and photos from the Saskatchewan Anti-Tuberculosis League not directly linked to the sanatoriums. This includes mass surveys, vaccination campaigns, ACT Shows, and other topics pertaining to general operation in the province.

This fonds contains material related to the administration, programing, and information services of the USSU Women’s Centre in its various incarnations as well as informational brochures, reports, clippings and reference material on a variety of subjects of particular concern to women.

This fonds contains correspondence, reports, studies, minutes, articles and speeches documenting the interests and career of Dr. Matthews. The bulk of the material deals with health care in general and Medicare in particular.

This fonds contains correspondence; minutes; reports; working papers; briefs and submissions; both for the Advisory Planning Committee on Medical Care, and for the Oil and Gas Conservation Board. Additionally, there is material from Thompsons's tenure as President of the University of Saskatchewan; material related to the International Botanical Congress and the International Congress of Genetics; and several reference books, primarily dealing with Medicare in Canada and abroad.