Designed by Webster and Gilbert, architects, and built between 1948 and 1955 by Smith Bros. and Wilson, contractors, at a cost of $7,000,000.00, the 6-storey, 7-wing University Hospital was officially opened by Bentley, T.J., Saskatchewan Minister of Health on May 1955.The name was officially changed to Royal University Hospital 23 May 1990.

One of the five original campus buildings, the Livestock Pavilion (or Stock Pavilion as it was more commonly known) was designed by Brown and Vallance and constructed between 1910-1912 at a cost of $20,000. Built of red brick, the roof was a combination of slate and translucent glass panels, some of which could be opened for ventilation. The Pavilion included a large show arena, with seating for up to 500; the floor in this area remained earth, covered with straw or shavings, as it was felt concrete “might make the exercise of horses more dangerous than it should be.”

Early short courses offered by the University included butchering; the Pavilion had both a slaughter room and cold storage area. It also housed the first laboratory for the department of animal science. One design feature certainly dated it: the only washroom facilities were for men.

By 1986 there were concerns that the north wall of the Pavilion was unstable, and the building was slated for demolition in December of that year. It proved more durable than expected: the contractor had to search for a wrecking ball heavy enough to demolish the Pavilion’s roof. The demolition cost $43,000.

Hockey has been played at the University of Saskatchewan as long as there have been students to play it. In the early years both men and women braved the cold to play hockey on an outdoor rink situated just east of the Engineering Building. Built on the footprint of the original rink, Rutherford Rink was finished in 1929 and remains home to the Hockey Huskies. Whether their hockey has been played at the inter-collegiate or inter-mural level or in one of the regional leagues, students of the U of S have embraced Canada’s game and made it part of the student experience.

In 1990 the Huskies beat the St. Mary's Huskies of Halifax, 24-21 for their first Vanier Cup win. In 1996 the Huskies won their second championship by defeating the St. Francis Xavier X-Men 31-12. Saskatchewan won their third championship in 1998 by defeating the Concordia Stingers 24-17. All three games were played at Skydome in Toronto.

In the summer of 1914, the Canadian militia leased a part of the Sarcee (now Tsuu T'ina Nation) Indian Reserve as a prospective training site for military personnel. Sarcee Camp, as the site came to be known, was the only area in Alberta set aside to train soldiers for battle during World War I. More than 45,000 men from 30 units across the province trained at the camp over the course of the war. It was one of the largest military training areas in Canada at the time. Sarcee Camp was abandoned in 1998.

In 1910 the Saskatchewan Department of Agriculture turned over to the University the responsibility for the development and delivery of agricultural and women's extension programs throughout the Province. To fulfill this mandate, the Department of Agricultural Extension (1910) and Women's Work (1913) were established within the College of Agriculture. Initially the activities of Agricultural Extension focused on services to the Agricultural Societies--short courses, institutes (meetings and conferences), plowing matches, field crop contests, stock judging, etc. Starting during the war years, a Better Farming Train toured the province providing lectures and demonstrations and presenting exhibits on matters pertaining to agriculture. In 1915 "educational holidays" or camps were initiated for farm boys and girls and in 1918 4-H clubs were formed throughout Saskatchewan. Farm and Home Week, a period of exhibits, lectures, and demonstrations at the University, was introduced in the early 1930s. Special projects and programmes for rural women were offered through Homemakers Clubs, established in 1911. In addition to basic domestic activities, women received advice and instruction in fruit growing, tree planting, home nursing, water supply and purity, libraries, health and welfare services, etc. Adult Education services, begun in 1938 in response to forces for social reconstruction, consisted in part of groups formed to discuss planning, economics, cooperatives, government institutions and policies, international affairs, trade unions, etc. This was a logical expansion of the variety of information (bulletins, leaflets), informal (lectures, demonstrations), public (testing, analyses), professional (training), and cultural (drama, music) services, as well as a variety of services to governments at all levels. In 1949 the work of Agricultural Extension and Women's Work were combined in the Department of Extension. It remained a department in the College of Agriculture until 1963 when administrative responsibility was transferred to the Office of the President and renamed the Extension Division. Since the 1970s non-degree programs were offered in the areas of agriculture and horticulture, women, business, languages, indigenous people, community development, liberal studies, arts, seniors, science and technology, career development, and adult education. The name changed again in 1979 to Division of Extension and Community Relations. It was changed back to Extension Division in 1990. The Extension Department was disestablished on 1 July 2007, and replaced with three new departments.

Extension work was begun at the University of Saskatchewan in 1910 when the Minister of Agriculture, Motherwell, W.R., sent his superintendent of fairs and institutes, Auld, F.H., to head the Extension Department. Through the support of the College of Agriculture and the Extension Department, rural men and women were reached with such events and activities as the Better Farming Train and the Homemakers' Clubs.

Designed by Brown and Vallance, construction began on Qu’Appelle Hall in 1914 but was sporadic. Delays meant that some building material was subject to the war tax, an additional 5%; and over the winter of 1915 frost damaged the swimming pool, another of many unforeseen expenses. The building was finally completed in 1916, at a cost of $250,000. Originally known simply “Student’s Residence No. 2,” the name “Qu’Appelle Hall” was first mentioned in the minutes of the Board’s executive committee in September 1916. Designed as a men’s residence, construction began on Qu’Appelle Hall in 1914 but was sporadic. Delays meant that some building material was subject to the war tax, an additional 5%; and over the winter of 1915 frost damaged the swimming pool, another of many unforeseen expenses. The building was finally completed in 1916, at a cost of $250,000. It included a swimming pool, with lockers purchased from the YMCA, and the dining hall was immediately put to use as a gymnasium–facilities “rendering the Physical Training, which all must take, a pleasure not a penance.” As well as student quarters, Qu’Appelle Hall was used to provide office space and a place for a museum. Normal School (Education) used the first floor; some language classes were also taught there. In 1917 part of the building was used by Emmanuel students while returned soldiers studying Engineering used their building; and in the 1930s, the COTC was quartered in the north end of the Qu’Appelle Hall basement. The building was used for classes and offices until construction of the Arts building in 1960. In the early 1960s the Board of Governors decided that “there should be accommodation on campus for at least one-third of the out of town students,” and authorized an addition to Qu’Appelle to house another 60 students–an increase of 50%. The $731,000 addition, designed by Izumi, Arnott and Sugiyama, was completed in 1963.

The Shuttleworth Mathematical Society was designed to give students interested in mathematics an opportunity to meet in an informal setting, and was open to all students who had completed one math class and were registered in a second. The Society was originally formed in November 1916 as the University Mathematical Society. It was renamed in honour of Roy Eugene Shuttleworth, a brilliant honours student who had been the first president of the organization. Shuttleworth was born in 1896 in Leavenworth, Washington. He was a student at the University of Saskatchewan. He served as a private with the Princess Patricia's Canadian Light Infantry (Eastern Ontario Regiment). Shuttleworth died in combat during World War I on 26 August 1918 at Vimy Ridge, France. His name is inscribed on the Vimy Memorial. The society has been inactive for many years.

Promoted by the Saskatchewan Registered Nurses' Association, a School was established within the School of Medical Science in 1938. Initially the Bachelor of Science in Nursing degree was a 5-year program consisting of 2.5 years at the University followed by 2.5 years training in one of four affiliated hospitals located in Regina and Saskatoon. In 1950 the program was altered to 2 years at the University, 2 years at a hospital. and a final year back at the University. Three years later a 1-year program for Registered Nursed leading to a Diploma either in Public Health or in Teaching and Supervision was established. With the opening of [Royal] University Hospital in 1954, the hospital experience component at affiliated hospitals was discontinued. That year a basis 3-year diploma program was established. In 1967 nursing teachers became members of the University faculty and students were admitted to a new 4-year curriculum. The 3-year diploma program was phased out in 1969 and the 5-year in 1971. The School became a College in 1974. The following individuals have served as Directors or Deans: [Directors:] K.W. Ellis (1938-1950); H.B. Keeler (1950-1969); L.D. Willis (1969-1974); [Deans:] H.J. Kernen (1974-1980); U. Ridley (1981-1990); Y. Brown (1990- ).

With the opening of its Murray Point Summer School of Art at Emma Lake in 1936, the University of Saskatchewan became the first Canadian University to establish an outdoor art school. The classes were designed to be equivalent to winter session courses with an emphasis on the needs of students from small towns, the majority of whom were teachers. In 1955 the Regina Campus Art Department decided to establish a two-week professional artists' workshop. Many acclaimed painters, sculptors, and art critics, especially from New York, made the trip north to Emma Lake. With the creation of the University of Regina in 1974, the University of Saskatchewan took sole administrative responsibility for the Murray Point School. In 1989 the Emma Lake Art School was renamed the Kenderdine Campus. A. "Gus" Kenderdine was director of the school from 1936 to 1947.

Three string quartets bearing the name Amati have been based in Canada. Two separate Amati string quartets have performed on 17th-century instruments built by the Amati family of Italy, and owned by the University of Saskatchewan in Saskatoon. A third unrelated Amati String Quartet was based in Ontario, primarily Toronto, from 1985 to 2000. This first Amati String Quartet was founded in 1968 by Murray Adaskin and three other faculty members of the University of Saskatchewan: Norma Lee Bisha (second violin), Michael Bowie (viola), and Edward Bisha (cello). It gave its first concert on 2 February 1969. Later that same year, Robert Klose was named second violin and Norma Lee Bisha replaced Michael Bowie. The personnel remained stable until the group was supplanted in 1971 by the Canadian Arts Trio after fewer than 10 formal concerts. The quartet was too short-lived to develop a wide repertoire or a distinctive style. The University of Saskatchewan Amati Quartet in Residence was established in August 2003 and also played on the university’s Amati instruments. This quartet had previously been known as the Cole Quartet. The initial members were Marla Cole (1968-2017) first violin), Michael Swan (second violin), Geoff Cole (viola) and Linda Bardutz (cello). In 2004, Luke Henny became second violinist and Peter Hedlin replaced Bardutz as cellist. The Amati Quartet performs a yearly recital series, including a Thanksgiving Monday concert, and plays at various University of Saskatchewan events. It performed for Queen Elizabeth II in honour of Saskatchewan’s 100th anniversary in May 2005, and since its opening season has undertaken a project to perform all of Haydn’s string quartets. The Amati instruments at the University of Saskatchewan — one violin built in 1627, another violin built in 1637, the viola in 1607 and the cello in 1690 — are the only set in Canada built by the Amati family of Cremona. The viola’s back bears the painted crest of the Borghese family that commissioned it. All were purchased by Kindersley, Sask. collector Stephen Kolbinson (1888-1986) and sold to the university in 1959 for $20,000 on the condition that the university establish an Amati string quartet. The Canadian Arts Trio (active 1971–1975) — which comprised Robert Klose (violin), Edward Bisha (cello) and Robin Harrison (piano) — used two of the four Amati instruments owned by the university. The Amati instruments were lent to Victoria's Lafayette Quartet 1992-1998. They have also occasionally been played by members of the Saskatoon Symphony Orchestra. The estimated value of the instruments is approximately $3 million (2020).

Trophy honouring Dr. Neil B. Hutcheon who was professor of Mechanical Engineering from 1937-1953.

The Rutherford Memorial Trophy was first awarded around 1949 by the Saskatchewan Agricultural Graduates Association for competition during its annual Farm Week Bonspiel. The trophy honoured W.J. Rutherford, first dean of Agriculture. The names of all the members of the class of 1912 are engraved on a plate on the back of the trophy.

The Bible of Borso d'Este is a two volume manuscript. The illuminated miniatures, work of Italian Taddeo Crivelli and others, were executed between 1455 and 1461.

Though the first recorded withdrawal from the University Library occurred in October 1909, nearly five decades passed before the Library had its own building. The early collection was housed either on the second floor of the College Building, later known as the Administration Building, or was scattered among a number of small departmental libraries. Plans for a new library building in the late 1920s were ended by the start of the Great Depression; but a dramatically reduced acquisitions budget was offset by a grant from the Carnegie Corporation in 1933. In 1943 the University hired its first professional Librarian.

A combination of provincial grants and University fundraising financed the construction of the Murray Memorial Library. Named after the University’s first President, the H. K. Black design marked a change in campus architecture away from the more angular and elaborate Collegiate Gothic style to that of the less expensive cube. Building materials included granite at the entrance and Tyndall stone (the material greystone replaced in 1911) as a wall cladding and window trim. In addition to the library, the building housed the College of Law, an office of the Provincial Archives and a 105 seat lecture theatre equipped with the latest in audio visual teaching aids.

Over the next two decades the University Library System mirrored the expansion of the University in general. Branches were opened in Education, Health Sciences, Law, Engineering, Geography/Physics, Thorvaldson, and Veterinary Medicine. The most dramatic transformation took place between 1970 and 1976 when a six floor south wing was added along with an extensive renovation of the 1956 structure. Designed by BLM, Regina, the south wing was unlike any other building on campus. Clad in Tyndall stone panels made to look like concrete (through a "bush hammered" finish), the grey almost windowless building is industrial and utilitarian in appearance. The University's master plan required buildings in the core of campus to be clad in stone. However, the "bush hammered" finish was used since the Library addition was built during a period that saw the flowering of "Brutalist" Architecture, so called because of the wide use of exposed concrete. The new (south) wing, originally called the Main Library, was officially opened on 17 May 1974, and also became the home of the Department of Art and Art History, the College of Graduate Studies and the University Archives.