Assiniboia Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Assiniboia Presbytery, which had been part of the Presbyterian Synod of Saskatchewan.

The presbytery was divided and recreated several times, over the years. In 1926, it was split into Assiniboia Presbytery and the new Shaunavon Presbytery. In 1951, the two were reunited under the original name Assiniboia Presbytery. In 1959, the presbytery was divided along Highway 19: the western part was combined with Swift Current Presbytery, to become Cypress Hills Presbytery, and the eastern part was amalgamated with Weyburn Presbytery, under the name Assiniboia Presbytery.

In 1973, Assiniboia Presbytery was dissolved and its pastoral charges were divided between Moose Jaw Presbytery and Arcola-Estevan Presbytery (which became the new Souris Valley Presbytery).

Kamsack Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Kamsack Presbytery, which had been part of the Presbyterian Synod of Saskatchewan.

In 1956, Kamsack Presbytery amalgamated with Abernethy-Yorkton Presbytery, becoming Yorkton Presbytery.

Elrose Presbytery was created in 1926, from the division of Kindersley Presbytery. Early pastoral charges in the presbytery included Eston, Dinsmore, Ferndale (student field), Richlea, Lucky Lake, Annerly (student field), Tuberose, North Landing, Demaine-Beechy, Elrose, Plato, Macrorie, Wiseton, Buffalo Basin (student field), Glidden, Wartime, Dunblane (including BIrsay), Dunblane (Finnish), Eatonia (English and German congregations), Rankin (student field), Mantario, Lacadena, Sanctuary.

In 1949, the Presbyteries of Elrose and Kindersley amalgamated, to become Rosetown Presbytery.

Prince Albert Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Prince Albert Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union , in 1925, there had also been a Prince Albert District, in the Saskatchewan Conference of the Methodist Church.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Prince Albert Presbytery became part of the new Tamarack Presbytery.

Regina Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Regina Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Regina District, in the Saskatchewan Conference of the Methodist Church.

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Regina Presbytery became part of the new Wascana Presbytery.

Rosetown Presbytery was created in 1949, through the amalgamation of Elrose and Kindersley Presbyteries. Additional charges transferred over the years, including Springwater (moved from Battleford Presbytery, July 1, 1985).

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Rosetown Presbytery became part of the new Prairie Pine Presbytery.

Swift Current Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Swift Current Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Swift Current District, in the Saskatchewan Conference of the Methodist Church.

In 1959, the presbytery was amalgamated with part of Assiniboia Presbytery (west of Highway 19) and became Cypress Hills Presbytery.

Wilkie Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Wilkie Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Wilkie District, in the Saskatchewan Conference of the Methodist Church.

On July 1, 1961, the presbytery officially amalgamated with Battleford Presbytery, except for two pastoral charges (Biggar and Springwater), which became part of Rosetown Presbytery.

The Dominion Commission (officially "The Commission appointed pursuant to The United Church Act, chapter 100 of the Statutes of Canada, 1924") was formed to enable the distribution of property between the United Church of Canada, which about 70% of Presbyterian Churches in Canada joined, and the remaining "non-concurring" Presbyterian Church.

Kindersley Pastoral Charge was formed as a new United Church charge in 1925, part of Kindersley Presbytery and consisting of St. Paul's United Church (Kindersley). With the closure of Kindersley Presbytery, the charge became part of Rosetown Presbytery. Additional preaching points included Netherhill (from ca.1962 to 1968).

The United Church Woman's Association (W.A.) in Saskatchewan appears to have been formed by the 1950s, or possibly earlier. It primarily operated in local and presbytery-level units before the organization of the national-level Dominion Council of the Woman's Association, in 1940. Efforts of the W.A. generally supported the local church and community, while other organizations focused on education and world mission programs.

In 1962, United Church W.M.S. and W.A. organizations across the country amalgamated to form the United Church Women (U.C.W.). Presbyterial and local groups developed along similar lines to national bodies, becoming local and presbyterial U.C.W. units in January 1962.

The United Church Women (U.C.W.) was formed in 1962, from an amalgamation of United Church Woman's Missionary Society (W.M.S.) and Woman's Association (W.A.) organizations, across the country. Existing Women's Federation (W.F.) groups were also incorporated into the UCW. Local and Presbytery-level groups developed along similar lines to national bodies, becoming local and presbyterial U.C.W. units in January 1962.

In October 2012, Saskatchewan’s U.C.W. Conference Coordinating Committee voted to disband and be replaced by the Women of the United Church of Canada Network. The mandate of the new network included communicating and supporting U.C.W. activities.

Hafford Hospital was first built around 1922, by the Missionary Society of the Methodist Church. The first superintendent was the Rev. G. Dorey, who would later become Moderator of the United Church of Canada (successor to the Methodist Church in Canada). Dr. S.M. Scott was the first doctor to serve the hospital, followed by Dr. Rose, who was later joined by Dr. Paulson. The Hafford Hospital Ladies Aid Society, formed 1924, was involved in raising money to support hospital activities. After financial difficulties in the 1930s, the hospital was eventually closed, in 1941, due to lack of funds.

In 1946, the R.M. of Redberry and the Village of Hafford bought the building and its equipment from the Missionary Society, then re-opened it as the Hafford Union Hospital.