Promoted by the Saskatchewan Registered Nurses' Association, a School was established within the School of Medical Science in 1938. Initially the Bachelor of Science in Nursing degree was a 5-year program consisting of 2.5 years at the University followed by 2.5 years training in one of four affiliated hospitals located in Regina and Saskatoon. In 1950 the program was altered to 2 years at the University, 2 years at a hospital. and a final year back at the University. Three years later a 1-year program for Registered Nursed leading to a Diploma either in Public Health or in Teaching and Supervision was established. With the opening of [Royal] University Hospital in 1954, the hospital experience component at affiliated hospitals was discontinued. That year a basis 3-year diploma program was established. In 1967 nursing teachers became members of the University faculty and students were admitted to a new 4-year curriculum. The 3-year diploma program was phased out in 1969 and the 5-year in 1971. The School became a College in 1974. The following individuals have served as Directors or Deans: [Directors:] K.W. Ellis (1938-1950); H.B. Keeler (1950-1969); L.D. Willis (1969-1974); [Deans:] H.J. Kernen (1974-1980); U. Ridley (1981-1990); Y. Brown (1990- ).

In 1913 Abigail DeLury began 17 years as the Director of Women's Work in the Department of Extension, establishing Homemaker's Clubs (later, Saskatchewan Women's Institutes) to whom she taught homemaking skills and for whom she produced a variety of domestic science pamphlets. Instruction in household science began on campus in 1917 with the appointment of E.B. Rutter as instructor. The Department became a School within the College of Arts and Science in 1928 and the School became a College in 1942. In 1941 the degree program expanded from 3 to 4 years following senior matriculation. The name was changed from the College of Household Science to the College of Home Economics in 1952. The College was phased out in 1990. The following individuals served as Dean: G.H. Ling (1931-1940); H.H. Hunt (1940-1965); E.R. Simpson (1965-1971); M.J. Guilford [Acting] (1972); Helen Abell (1973-1974); M.J. Guilford [Acting] (1974-1976); D.L. Gibson (1976-1981); T.J. Abernathy (1981-1982); H.E. Nixon [Acting] (1982); G.M. Moss (1982-1987); Eva Lee (1987-1989); M. Crowle (1989-1990).

A School of Accounting was established in 1915 as part of the College of Arts and Science, with G.H. Ling, Professor of Mathematics and Dean of Arts and Science, as Head. Initially, only night classes were offered; in 1920, a complete 4-year course became available. The School was closely associated with the Institute of Chartered Accountants; a University Board of Examiners, chaired by Dean Ling, supervised the preparation and marking of examinations for the Institute. In 1936, the School was granted College status and formally separated from the College of Arts and Science. The College was renamed the College of Commerce in 1943 to reflect the expanded curriculum being offered to its students. The following individuals have served as Dean: G.H. Ling [School of Accounting] (1917-1936); J.A. Neilson [College of Accounting] (1936-1940); J.H. Thompson [College of Accounting] (1941-1943); J.H. Thompson (1943-1952); T.H. McLeod (1952-1961); Georgina Goodspeed [Acting] (1961-1962); T.H. McLeod (1962-1964); Georgina Goodspeed [Acting] (1964-1965); Lloyd Barber (1965-1969); Samuel Laimon (1969-1976); P.M. Maher (1976-1982); W.J. Brennan (1982-).

The Department of Chemistry was created in 1910 and offered classes in General Chemistry, Analysis, Organic and Physical Chemistry. To meet the demands of the various colleges and schools it served, the department expanded its offerings to include Cereal Chemistry, Industrial and Applied Chemistry. In 1922 Chemical Engineering was added to the department's responsibilities until 1982 when it became a separate Engineering department. The areas of research have been varied, ranging from applied research projects related to the natural resources of the province to pure science problems. From an early point in the department's development it provided analytical services to both the public and private sectors but with a reduction in demand this was discontinued in 1990. The following have served as head of the department: R.D. MacLaurin (1910-1919); T. Thorvaldson (1919-1948); J.W.T. Spinks (1948-1959); K.J. MacCallum (1959-1970); J.M. Pepper (1970-1976); A.R. Knight (1976-1981); D.R. Grant (1981-1984); J.R. Woods (1984-1989); W.L. Waltz (1989-1994).

The Centre for Community Studies, a joint University-Government program, was created in 1957. Its objective was to undertake research, disseminate knowledge and offer specialized advice with respect to the applied social sciences and the processes of community education. It specialized in the theory and practice of community change and development, using an inter-disciplinary approach: its staff came from sociology, economics, anthropology, social psychology, and history. In 1966 the Centre was incorporated as the Canadian Centre for Community Studies, with a head office in Ottawa.

"The building is the first one, and for many years will occupy the place of honor, and even in later years, when the principal buildings have been built, its position is such that it deserves thorough study to develop the architectural possibilities." - David Brown to Walter Murray, 5 November 1909.

Designated as a provincial heritage property in 1982 and as a National Historic Site in 2001, the University's first building has long served as the architectural, intellectual and emotional cornerstone of the campus.

Designed by Brown and Vallance, the College Building was originally intended ultimately to house the College of Agriculture; but from the start, served numerous purposes. As early as April 1910, the floor plan included space for milk testing, butter making, cheese making, grain work; a gymnasium; several classrooms; offices for the Registrar, Dean of Agriculture, Director of Extension, and President; the original "faculty club"; laboratories; the library; and quarters for the janitor. After a sod-turning ceremony on 4 May 1910, the cornerstone was laid by Prime Minister Wilfrid Laurier on 29 July 1910. It was constructed between 1910-12 by Smith Bros. and Wilson general contractors. Completed in 1912, the building was officially opened by Walter Scott, Premier of Saskatchewan on 1 May 1913.

The College Building serves as a memorial to much of the University's history: numerous plaques to individuals and organizations can be found in its interior, including memorial ribbons honouring members of the university community who served in the First World War. In 1997, the University created "Nobel Plaza" in front of the College Building, honouring two Nobel Laureates associated with the University: Gerhard Herzberg and Henry Taube.

As the University grew, the College Building gradually became the administrative centre for the University. By the 1950s, most of the original teaching facilities were taken over by new or expanded offices including those of the registrar, controller, alumni and news services, and presidential staff. The building became known as the Administration Building at this point, and later the "old Administration Building" to distinguish it from the new wing.

This expansion continued through the 1960s and 1970s, particularly with the appointment of a university secretary and vice-presidents. While Convocation Hall became too small for regular Convocation ceremonies by 1930, it maintained its original, broader function as a venue for concerts, meetings, lectures, and other events.

Parts of the building were declared to be unsafe in 1979, which led to the construction of the new wing of the Administration Building, opened in 1987. Most of the original building was closed, but Convocation Hall remained in use until 1997.

The building was reopened and officially rededicated as the College Building in September 2005 after a major rehabilitation project. The rehabilitation was reported to be "one of the largest heritage conservation projects in Canada - second only to the work being done on Parliament Hill." In addition to senior administrative offices and Convocation Hall, the College Building became home to the Museum of Antiquities and new gallery space for the University Art Collection.

Henry Unger was a Canadian Pacific Railway man who helped with the Fred Finch farm near Lanigan, Saskatchewan.

Ian William Tweddell was born on 12 January 1917 in County Durham, England. He emigrated to Canada with his parents in 1921, settling near Lashburn, Saskatchewan. Tweddell was educated in Lashburn and Prince Albert, prior to enrolling at the University of Saskatchewan, where he received a BSc in Civil Engineering (1948). He went on to the University of Manitoba, earning an MSc in Community Planning. He served in the RCAF and RAF from 1941 to 1945, and was a prisoner of war in Germany from 1942 to 1945. Tweddell worked as a surveyor, throughout Saskatchewan, Northwest Territories and Yukon. He joined the faculty of Civil Engineering at the University of Saskatchewan in 1957 as a Lecturer, and was promoted to Assistant Professor in 1962. Tweddell remained with the College of Engineering until his sudden death on 23 June 1975.

Edward Archer Tollefson attended Saskatoon's Nutana Collegiate before enrolling at the University of Saskatchewan, where he earned both a BA (1954) and a LL.B. (1956). Tollefson went on to study law at Oxford on an IODE overseas scholarship and was awarded a BCL in 1958. He joined the faculty of the College of Law that year as an Instructor and received several promotions before becoming a full Professor in 1968. He resigned in the spring of 1971. He taught courses in constitutional law, legal process and remedies, legal writing, evidence and comparative law. He also authored the book "Bitter Medicine" (1964), an overview of medical care legislation in Western Canada.

Mabel Frances Timlin was born in Forest Junction, Wisconsin on December 6, 1891. She attended Normal School in Wisconsin and taught for 10 years at various schools in Wisconsin and Saskatchewan, prior to accepting a position as a secretary at the University of Saskatchewan in 1921. Taking a few classes a year, she earned a BA in 1929 and then completed her PhD in 1940 from the University of Washington during summer sessions. Timlin began lecturing in Economics at the University of Saskatchewan in 1935. She was promoted to full Professor in 1950 and retired in 1959. Timlin was the first tenured female Economics professor at a Canadian university. Timlin was an authority on Keynesian economic theory, monetary policy, and immigration. Among her many publications were "Keynesian Economics" (1942) and "Does Canada Need More People?" (1951). Following her retirement, the Canada Council granted her a special Fellowship to study Canadian immigration. Later, she was appointed research assistant with the Social Science Research Council of Canada and co-authored "The Social Sciences in Canada: Two Studies" (1968). She was a Fellow of the Royal Society of Canada, first woman president of the Canadian Political Science Association, and a member of the Order of Canada. Timlin was awarded an honorary Doctor of Laws from the University of Saskatchewan in 1969. Timlin died in Saskatoon on September 20, 1976 at the age of 84.

Born in Nottingham, England, Joseph H. Thompson received his early education in Saskatoon. Enlisting for service in the Great War, he joined the RAF overseas. Badly injured in a crash he lost the sight of one eye and the other was seriously impaired. He later became an accountant with his own practice in Saskatoon until 1938 when he became an accounting instructor at the university. Thompson became dean of the School of Accounting in May 1940 and also took over command of the COTC that same month. He continued as dean of the newly named College of Commerce from 1944-1951. Thompson’s command came to an end 21 March 1947 having served with the COTC since 1921 (with the exception of Active Service in Regina from 1939 to 1940). In addition to being Dean of Commerce he was chairman of the Board of Governors of Emmanuel College. He had retained his military affiliations as aide-de-camp to lieutenant governors J. M. Ulrich and William J. Patterson and was also Honorary Lieutenant-Colonel of the COTC. Thompson died suddenly on 9 March 1952 at 55 years of age.

Ida Thompson lived in Saskatchewan and held various government and community positions during the early part of the 20th century including Principal Clerk in charge of land registers and technical staff of the School Lands Branch and editor of the Topographical Survey of Canada. She was a civil servant and author.

Sandra (Therrien) Schemmer, a graduate of West Vancouver Secondary, enrolled at the University of Saskatchewan (BA, 1959) in 1957. She was a member of the Huskiette basketball team for three years, leading the team in scoring in 1957. Sandra was also on the swim team for three years. In addition to participating in sports, Therrien served on the Women's Athletic Board for two years and worked for The Sheaf as a roving reporter.

David Thauberger was born in Holdfast. He studied ceramics at the University of Saskatchewan, Regina Campus, where ceramic sculptor David Gilhooly served as an early mentor, inspiring Thauberger and others to create art that was rooted in their own life experience and their own geographical region. He earned his BFA in 1971 and his MA in 1972 from California State University (Sacramento). He then studied with Rudy Autio at the University of Montana in Missoula, earning his MFA in 1973.
David Thauberger is known for his paintings of the vernacular architecture and cultural icons of Saskatchewan. Thauberger's achievements were recognized when he was awarded the Saskatchewan Order of Merit. He was invested as a Member of the Order of Canada in 2008, is a recipient of the Queen's Diamond Medal in 2012, the Lieutenant Governor's Saskatchewan Artist Award in 2009 and is member of the Royal Canadian Academy of Arts. When named as a Member of the Order of Canada, he was cited for his contributions to "the promotion and preservation of Canadian heritage and folk art in the province of Saskatchewan, in addition to his work as a painter, sculptor and educator."
Thauberger has become known as an iconoclastic artist, creating colourful portraits of vernacular prairie buildings, legion halls, quonset huts, false fronted shops and inner-city bungalows.