Hafford Hospital was first built around 1922, by the Missionary Society of the Methodist Church. The first superintendent was the Rev. G. Dorey, who would later become Moderator of the United Church of Canada (successor to the Methodist Church in Canada). Dr. S.M. Scott was the first doctor to serve the hospital, followed by Dr. Rose, who was later joined by Dr. Paulson. The Hafford Hospital Ladies Aid Society, formed 1924, was involved in raising money to support hospital activities. After financial difficulties in the 1930s, the hospital was eventually closed, in 1941, due to lack of funds.

In 1946, the R.M. of Redberry and the Village of Hafford bought the building and its equipment from the Missionary Society, then re-opened it as the Hafford Union Hospital.

The Board of Home Missions, constituted in 1926, was responsible for supervising and administering all the mission work of the United Church in Canada. This encompassed working among Indigenous peoples, French Canadians, immigrants, and ethno-cultural communities; maintaining missions in marine, urban, and rural areas; overseeing chaplaincies and student charges; supporting church extension in new communities; running institutions including inner city missions, youth centres, children's homes, All Peoples' Missions, hospitals, and schools; and undertaking other forms of community and social service work. This Board was incorporated into the new Division of Mission in Canada in 1972.

The Board of Christian Education was established in 1932, with the amalgamation of the former Boards of Education, with responsibility for colleges and secondary schools, and the former Board of Religious Education, with responsibility for leadership in children's, youth and adult work within and outside of the Church. The Board was responsible for the entire educational programme of the Church, in schools, churches and the home. In 1942, the Board's responsibility for the theological colleges and secondary schools of the Church was transferred to the new Board of Colleges and Secondary Schools. The Board of Christian Education was originally structured around Departments for children, youth, young people and adults, and functional committees for administration of leadership training, field administration, curriculum and interdenominational work in Christian education. The Board was headed by a Secretary with two Associate Secretaries and several men and women appointed to operate specific activities such as boys' work and girls' work.

The Board was reorganized and added to the Division of Congregational Life and Work upon its establishment in 1964; many of the standing committees were discontinued and in their place staff sections were developed, one for each age group (children, youth, young people, adults) with an Associate Secretary in charge of each section. The Department of Sunday School Publications, late of the Board of Publication, was incorporated into its various programme areas. The Board had responsibility for the New Curriculum, the numerous children's and youth groups within the Church as well as for providing classes and assistance for adults. In 1972 the Board was made a part of the new Division of Mission in Canada.

The Division of World Outreach was created by General Council in 1972 out of the Board of World Mission and became operational in July 1973 . The new Division promoted mutuality in mission and interdenominational cooperation; it divided its administrative framework into geographic areas, including Africa, Asia, Latin America and Caribbean, South Asia and Pacific.

Nokomis Pastoral Charge was formed as a new United Church charge in 1925, containing the preaching points at Nokomis and Richfarms. Later additions included Saline (ca.1936), and Rowanville (ca.1940). By 1946, Richfarms had moved to Lockwood Pastoral Charge and the only points listed in Nokomis Pastoral Charge were Duff, Lorlie and Nokomis. As of 1951, the points at Duff and Lorlie had moved to Pheasant Forks Pastoral Charge and Nokomis Pastoral Charge consisted of Richfarms (again) and Lockwood. By 1962, Richfarms was no longer listed in the charge.

Around 1977, Nokomis and Govan amalgamated into the new Nokomis-Govan Pastoral Charge, with points at Duval, Govan, Lockwood and Nokomis. Lockwood closed June 30, 1981, and Duval closed July 1, 2000. On January 1, 2004, the remaining Nokomis and Govan preaching points divided: Govan joined Semans-Raymore-Punnichy to created the new Crossroads Pastoral Charge; Nokomis amalgamated with Lanigan Pastoral Charge (containing Knox United Church, Lanigan), creating Lanigan-Nokomis Pastoral Charge.

Kennedy Pastoral Charge was formed as a new United Church charge in 1925, part of Qu'Appelle Presbytery. Around 1926, preaching points High View, Fletwode, and Fish Lake were added to the charge. By 1951, Golden Plain, Poplar Grove, and Langbank were also included, under the re-named Kennedy-Langbank Pastoral Charge. Around the 1970s, the name changed back to Kennedy Pastoral Charge. By the early 1990s, Highview was no longer listed and, as of 1992, only Kennedy and Langbank remained in the charge.

Brora Pastoral Charge was formed as a new United Church charge in 1925, part of Regina Presbytery and consisting of Brora, Tregarva and Rose Plain appointments. Balgonie joined the charge around 1965 and both Brora and Balgonie points moved to Regina St. Aidan's Pastoral Charge by 1970. Brora Pastoral Charge was re-established around 1973, with ministry supplied from Regina Rosemont.

The charge was officially closed on June 28, 2015.

Moose Jaw Grandview Pastoral Charge was formed after the dissolution of the joint Moose Jaw Trinity-Grandview Pastoral Charge, in June 2001. The charge officially closed on June 30, 2012.

Craik Pastoral Charge was formed as a new United Church charge in 1925, part of Regina Presbytery and containing preaching points at Craik and Rose Hill. The charge has also included Aylesbury, Foxbury (ca.1951), Holdfast, and Penzance. Aylesbury United Church was closed June 30, 1999. Holdfast United Church was closed March 11, 2009.

Francis Pastoral Charge was formed as a new United Church charge in 1925, containing preaching points at Francis and Pleasant View. The charge closed June 1, 2007.

Regina Knox Pastoral Charge was formed as a new United Church charge in 1925, containing the preaching point Knox United Church, formerly Knox Presbyterian Church. The previous Presbyterian congregation dated back to around 1882. It built a church in 1885, at the corner of Scarth Street and 11th Avenue, and a later replacement in 1905.

In 1951, Knox United Church amalgamated with Metropolitan United Church, to become Knox-Metropolitan United Church (and Pastoral Charge), located on the site of the former Metropolitan United Church, at the corner of Victoria Avenue and Lorne Street.