Rosetown Presbytery was created in 1949, through the amalgamation of Elrose and Kindersley Presbyteries. Additional charges transferred over the years, including Springwater (moved from Battleford Presbytery, July 1, 1985).

In 2000, Saskatchewan Conference went from 10 presbyteries to 7, with each adopting a new name. Most pastoral charges from Rosetown Presbytery became part of the new Prairie Pine Presbytery.

Swift Current Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Swift Current Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Swift Current District, in the Saskatchewan Conference of the Methodist Church.

In 1959, the presbytery was amalgamated with part of Assiniboia Presbytery (west of Highway 19) and became Cypress Hills Presbytery.

Wilkie Presbytery was one of the original 16 presbyteries established by the first General Council of the United Church of Canada (June 1925), to be part of the new Saskatchewan Conference. Initial boundaries were based on the previous Wilkie Presbytery, which had been part of the Presbyterian Synod of Saskatchewan. Prior to Union, in 1925, there had also been a Wilkie District, in the Saskatchewan Conference of the Methodist Church.

On July 1, 1961, the presbytery officially amalgamated with Battleford Presbytery, except for two pastoral charges (Biggar and Springwater), which became part of Rosetown Presbytery.

D.S. Dix was a prominent Presbyterian and then United Church clergyman, whose work included serving as minister to Saskatoon's Westminster Church, as lecturer and professor at the Presbyterian Theological College – which became St. Andrew's College – in Saskatoon, as Principal of St.Andrew's College, and as President of Saskatchewan Conference.

Born in 1875, in Woodbridge (York County), Ontario, Dix trained as a teacher and taught for 6 years before enrolling in the Presbyterian Knox College (University of Toronto). He graduated with a degree in theology, in 1907, and pursued further studies in divinity at Glasgow University (Scotland), the University of Chicago, and Union Seminary (New York). He served as minister to St. James Church (Dartmouth, Nova Scotia), 1908-1910, to Chalmers Church (Guelph, Ontario), 1910-1913, and Westminster Church (Saskatoon), 1913-1919. Dix was also a lecturer and then professor at the Presbyterian Theological College, which became St. Andrew's College (Saskatoon), under its first Principal, Rev. E.H. Oliver. In 1935, Dix was appointed Principal of the College, after the death of E.H. Oliver.

In June 1946, Dix officially retired but remained associated with St. Andrew's College. He served on the United Church Board of Overseas Missions and as President of Saskatchewan Conference (1934-1935). He was Conference Archivist (1947-1953), and chairman of the Conference Historical Committee until his death, in 1956.

Emerick Csendes was a missionary and later United Church minister in Saskatchewan and Manitoba. He was born in Transylvania, southeast Hungary, in October 1886. From 1914-1919, he served in the army and was promoted to the rank of Lieutenant. In 1924, Csendes left to become a missionary in Western Canada. He worked with Hungarian congregations in Manitoba and Saskatchewan – at Bekevar and Otthon – and studied at St. Andrew’s College (Saskatoon), from 1925 to 1928. He served in Winnipeg from 1929 until 1934, when he transferred to the Rothermere Mission field (Battleford Presbytery). In 1940, he returned to Otthon-Halmok Patoral Charge (Yorkton Presbytery), where he remained until 1951, when he transferred to Toronto’s Church of All Nations. He retired around 1956.

The Dominion Commission (officially "The Commission appointed pursuant to The United Church Act, chapter 100 of the Statutes of Canada, 1924") was formed to enable the distribution of property between the United Church of Canada, which about 70% of Presbyterian Churches in Canada joined, and the remaining "non-concurring" Presbyterian Church.

Kindersley Pastoral Charge was formed as a new United Church charge in 1925, part of Kindersley Presbytery and consisting of St. Paul's United Church (Kindersley). With the closure of Kindersley Presbytery, the charge became part of Rosetown Presbytery. Additional preaching points included Netherhill (from ca.1962 to 1968).

The United Church Woman's Association (W.A.) in Saskatchewan appears to have been formed by the 1950s, or possibly earlier. It primarily operated in local and presbytery-level units before the organization of the national-level Dominion Council of the Woman's Association, in 1940. Efforts of the W.A. generally supported the local church and community, while other organizations focused on education and world mission programs.

In 1962, United Church W.M.S. and W.A. organizations across the country amalgamated to form the United Church Women (U.C.W.). Presbyterial and local groups developed along similar lines to national bodies, becoming local and presbyterial U.C.W. units in January 1962.

The United Church Women (U.C.W.) was formed in 1962, from an amalgamation of United Church Woman's Missionary Society (W.M.S.) and Woman's Association (W.A.) organizations, across the country. Existing Women's Federation (W.F.) groups were also incorporated into the UCW. Local and Presbytery-level groups developed along similar lines to national bodies, becoming local and presbyterial U.C.W. units in January 1962.

In October 2012, Saskatchewan’s U.C.W. Conference Coordinating Committee voted to disband and be replaced by the Women of the United Church of Canada Network. The mandate of the new network included communicating and supporting U.C.W. activities.

Hafford Hospital was first built around 1922, by the Missionary Society of the Methodist Church. The first superintendent was the Rev. G. Dorey, who would later become Moderator of the United Church of Canada (successor to the Methodist Church in Canada). Dr. S.M. Scott was the first doctor to serve the hospital, followed by Dr. Rose, who was later joined by Dr. Paulson. The Hafford Hospital Ladies Aid Society, formed 1924, was involved in raising money to support hospital activities. After financial difficulties in the 1930s, the hospital was eventually closed, in 1941, due to lack of funds.

In 1946, the R.M. of Redberry and the Village of Hafford bought the building and its equipment from the Missionary Society, then re-opened it as the Hafford Union Hospital.