Regina Eastside Pastoral Charge was created as Prince of Peace Pastoral Charge (from the main preaching point), a new church development, on September 6, 1987. On January 1, 1998, the charge was renamed Eastside Pastoral Charge.

Regina St. John's Pastoral Charge was formed around 1954, part of Regina Presbytery and containing the new St. John's United Church, built at McTavish Street and Fourth Avenue, Regina. The decision to have a new building had resulted from a presbytery Church Extension Committee survey (ca.1951) that determined the district of the city required facilities not available at the existing Sixth Street United Church. The first service in the new St. John's United Church was held November 14, 1954. The pastoral charge closed June 30, 1999.

The congregation at Knox Presbyterian Church appears to date back to around 1882, building a church in 1885, at the corner of Scarth Street and 11th Avenue, and a later replacement in 1905. Knox joined the United Church of Canada in 1925. In 1951, Knox United Church amalgamated with Metropolitan United Church, to become Knox-Metropolitan United Church (and Pastoral Charge), located on the site of the former Metropolitan United Church, at the corner of Victoria Avenue and Lorne Street.

Built around 1912, Metropolitan Methodist Church became Metropolitan United Church in 1925 (part of the United Church of Canada). It was later re-named Knox-Metropolitan United Church, with the amalgamation of downtown Regina's Knox United Church and Metropolitan United Church.